Construction of Pyrrolocoumarin Cores through Double C-H Annulation Cascade

被引：7
|
作者：
Michikita, Ryudai [1 ]
Usuki, Yoshinosuke [1 ]
Satoh, Tetsuya [1 ]
机构：
[1] Osaka City Univ, Dept Chem, Grad Sch Sci, Sumiyoshi Ku, 3-3-138 Sugimoto, Osaka 5588585, Japan
来源：
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2022年 / 2022卷 / 22期
关键词：
Annulation; C-C coupling; C-H activation; Homogeneous catalysis; Rhodium; CATALYZED OXIDATIVE COUPLING/CYCLIZATION; LAMELLARIN ALKALOIDS; COUPLING REACTIONS; INTERNAL ALKYNES; ACTIVATION; FUNCTIONALIZATION; CLEAVAGE; BENZYLAMINES; BENZAMIDES;
D O I：
10.1002/ejoc.202200550
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Rhodium(III)-catalyzed double C-H annulation of 3-(acetylamino)coumarins with internal arylacetylenes is reported. The reaction proceeds smoothly accompanied by two C-C and two C-N bond formation to produce 8-aryl-6H- chromeno[4',3':4,5]pyrrolo[2,1-a]isoquinolin-6-ones selectively. It also provides a straightforward route to natural product inspired pentacyclic pyrrolocoumarin derivatives from readily available building blocks.
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页数：4
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