Iron(III) chloride-catalyzed convenient one-pot synthesis of β-acetamido carbonyl compounds

被引：69

作者：

Khan, Abu T. ^{[1
]}

Parvin, Tasneem ^{[1
]}

Choudhury, Lokman H. ^{[1
]}

机构：

[1] Indian Inst Technol Guwahati, Dept Chem, Gauhati 781039, India

来源：

TETRAHEDRON | 2007年 / 63卷 / 25期

关键词：

D O I：

10.1016/j.tet.2007.04.019

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A one-pot multi-component reaction of aldehydes, enolizable ketones or 1,3-dicarbonyls, acetonitrile/ benzonitrile, and acetyl chloride is described for the preparation of beta-acetamido carbonyl compounds using FeCl3 center dot 6H(2)O as a mild, inexpensive, and highly efficient catalyst. The effect of substrate as well as substituent for multi-component reaction versus Knoevenagel condensation is also illustrated. The key features of this methodology are operational simplicity, mild reaction conditions, and good yields. (C) 2007 Published by Elsevier Ltd.

引用

页码：5593 / 5601

页数：9

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