Correlation between oxidation potentials and inhibitory effects on Epstein-Barr virus activation of flavonoids

被引：15

作者：

Koyama, Junko ^{[1
]}

Morita, Izumi ^{[1
]}

Kobayashi, Norihiro ^{[1
]}

Konoshima, Takao ^{[2
]}

Takasaki, Midori ^{[2
]}

Osakai, Toshiyuki ^{[3
]}

Tokuda, Harukuni ^{[4
]}

机构：

[1] Kobe Pharmaceut Univ, Fac Pharmaceut Sci, Higashinada Ku, Kobe, Hyogo 6588558, Japan

[2] Chiba Inst Sci, Fac Pharmaceut Sci, Choshi 2880025, Japan

[3] Kobe Univ, Grad Sch Sci, Dept Chem, Nada Ku, Kobe, Hyogo 6578501, Japan

[4] Kyoto Prefectural Univ Med, Dept Mol Biochem, Kyoto 6020841, Japan

来源：

CANCER LETTERS | 2008年 / 263卷 / 01期

关键词：

oxidation potential; flavonoid; Epstein-Barr virus early antigen; cyclic voltammetry;

D O I：

10.1016/j.canlet.2007.12.016

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The oxidation potentials of fifteen flavonoids in phosphate buffer at pH 7.2 were determined by cyclic voltammetry. A good correlation was found between these oxidation potentials and the ability of flavonoids to inhibit Epstein-Barr virus early antigen (EBV-EA) activation. Furthermore, multiple regression analysis revealed that the solvent-accessible surface area (SASA) was a useful parameter for estimating the inhibitory effects of flavonoids on EBV-EA activation. (C) 2007 Elsevier Ireland Ltd. All rights reserved.

引用

页码：61 / 66

页数：6

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