Metabolic networks of the human gut microbiota

被引：24

作者：

Selber-Hnatiw, Susannah ^{[1
]}

Sultana, Tarin ^{[1
]}

Tse, W. ^{[1
]}

Abdollahi, Niki ^{[1
]}

Abdullah, Sheyar ^{[1
]}

Al Rahbani, Jalal ^{[1
]}

Alazar, Diala ^{[1
]}

Alrumhein, Nekoula Jean ^{[1
]}

Aprikian, Saro ^{[1
]}

Arshad, Rimsha ^{[1
]}

Azuelos, Jean-Daniel ^{[1
]}

Bernadotte, Daphney ^{[1
]}

Beswick, Natalie ^{[1
]}

Chazbey, Hana ^{[1
]}

Church, Kelsey ^{[1
]}

Ciubotaru, Emaly ^{[1
]}

D'Amato, Lora ^{[1
]}

Del Corpo, Tavia ^{[1
]}

Deng, Jasmine ^{[1
]}

Di Giulio, Briana Laura ^{[1
]}

Diveeva, Diana ^{[1
]}

Elahie, Elias ^{[1
]}

Gordon, James ^{[1
]}

Frank, Marcel ^{[1
]}

Furze, Emma ^{[1
]}

Garner, Rebecca ^{[1
]}

Gibbs, Vanessa ^{[1
]}

Goldberg--Hall, Rachel ^{[1
]}

Goldman, Chaim Jacob ^{[1
]}

Goltsios, Fani-Fay ^{[1
]}

Gorjipour, Kevin ^{[1
]}

Grant, Taylor ^{[1
]}

Greco, Brittany ^{[1
]}

Guliyev, Nadir ^{[1
]}

Habrich, Andrew ^{[1
]}

Hyland, Hillary ^{[1
]}

Ibrahim, Nabila ^{[1
]}

Iozzo, Tania ^{[1
]}

Jawaheer-Fenaoui, Anastasia ^{[1
]}

Jaworski, Julia Jane ^{[1
]}

Jhajj, Maneet Kaur ^{[1
]}

Jones, Jermaine ^{[1
]}

Joyette, Rodney ^{[1
]}

Kaudeer, Samad ^{[1
]}

Kelley, Shawn ^{[1
]}

Kiani, Shayesteh ^{[1
]}

Koayes, Marylin ^{[1
]}

Amy-Aminta, Abby Johanna ^{[1
]}

Kpata, Lena ^{[1
]}

Maingot, Shannon ^{[1
]}

机构：

[1] Concordia Univ, Biol Dept, 141 Sherbrooke St W,SP-375-09, Montreal, PQ H4B 1R6, Canada

来源：

MICROBIOLOGY-SGM | 2020年 / 166卷 / 02期

关键词：

human gut microbiota; microbiota-host interaction; gut ecology; metabolic networks; genetic regulation; diet; food additives; metabolic disease; obesity; type; 2; diabetes; atherosclerosis; bariatric surgery; exercise; CHAIN FATTY-ACIDS; ROUX-EN-Y; PROTEIN-COUPLED RECEPTOR; TRIMETHYLAMINE-N-OXIDE; DIET-INDUCED OBESITY; THERAPEUTICALLY MODIFIED BACTERIA; LAPAROSCOPIC SLEEVE GASTRECTOMY; VERTICAL BANDED GASTROPLASTY; COLONIC EPITHELIAL-CELLS; GLUCAGON-LIKE PEPTIDE-1;

D O I：

10.1099/mic.0.000853

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The human gut microbiota controls factors that relate to human metabolism with a reach far greater than originally expected. Microbial communities and human (or animal) hosts entertain reciprocal exchanges between various inputs that are largely controlled by the host via its genetic make-up, nutrition and lifestyle. The composition of these microbial communities is fundamental to supply metabolic capabilities beyond those encoded in the host genome, and contributes to hormone and cellular signalling that support the dynamic adaptation to changes in food availability, environment and organismal development. Poor functional exchange between the microbial communities and their human host is associated with dysbiosis, metabolic dysfunction and disease. This review examines the biology of the dynamic relationship between the reciprocal metabolic state of the microbiota-host entity in balance with its environment (i.e. in healthy states), the enzymatic and metabolic changes associated with its imbalance in three well-studied diseases states such as obesity, diabetes and atherosclerosis, and the effects of bariatric surgery and exercise.

引用

页码：96 / 119

页数：24

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