Synthesis of optically active γ-lactones via lipase-catalvzed resolution

被引：17

作者：

Shimotori, Yasutaka ^{[1
]}

Nakahachi, Yukihiko ^{[1
]}

Inoue, Keita ^{[1
]}

Miyakoshi, Tetsuo ^{[1
]}

机构：

[1] Meiji Univ, Sch Sci & Technol, Dept Appl Chem, Tama Ku, Kawasaki, Kanagawa 2148571, Japan

来源：

FLAVOUR AND FRAGRANCE JOURNAL | 2007年 / 22卷 / 05期

关键词：

gamma-lactone; novozym; 435; kinetic resolution; n-methyl-4-hydroxyalkanamide; n-methyl-4-acetoxyalkanamide;

D O I：

10.1002/ffj.1816

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Both enantiomers of the six major kinds of gamma-lactones were synthesized to >98% e.e. in four steps, starting from succinic anhydride. The key features were the syntheses of the various rac-N-methyl-4-hydroxyalkanamides via Grignard reaction and the enantioselective acetylation and hydrolysis promoted by Novozym 435. Copyright (c) 2007 John Wiley & Sons, Ltd.

引用

页码：421 / 429

页数：9

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