Differentially expressed genes in the liver of lean and fat chickens

被引：8
|
作者：
He, Q. [1 ,2 ,3 ]
Wang, S. Z. [1 ,2 ,3 ]
Leng, L. [1 ,2 ,3 ]
Na, W. [1 ,2 ,3 ]
Wang, Q. G. [1 ,2 ,4 ]
Li, H. [1 ,2 ,3 ]
机构：
[1] Minist Agr, Key Lab Chicken Genet & Breeding, Harbin, Peoples R China
[2] Educ Dept Heilongjiang Prov, Key Lab Anim Genet Breeding & Reprod, Harbin, Peoples R China
[3] Northeast Agr Univ, Coll Anim Sci & Technol, Harbin, Peoples R China
[4] Chongqing Acad Anim Sci, Chongqing, Peoples R China
来源：
GENETICS AND MOLECULAR RESEARCH | 2014年 / 13卷 / 04期
基金：
中国国家自然科学基金;
关键词：
Chicken; Lean and fat broiler lines; Chicken liver; Gene expression profile; MICROARRAY ANALYSIS;
D O I：
10.4238/2014.December.19.3
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
This study aimed to investigate gene expression in the chicken liver for lean and fat broiler lines. Birds used in this study were 2 and 4 weeks of age; they were derived from the 14th generation of Northeast Agricultural University broiler lines, which were divergently selected based on abdominal fat content. Chicken Genome Arrays were used to screen differentially expressed genes in the liver tissue from lean and fat birds. At 2 and 4 weeks of age, 770 and 452 genes were differentially expressed between the 2 lines, respectively. The differentially expressed genes were involved in Wnt, insulin signaling, and cell cycle pathways. At 2 and 4 weeks, 42 shared, differentially expressed genes were revealed by the analysis. We speculate that these genes might regulate chicken lipid metabolism.
引用
收藏
页码：10823 / 10828
页数：6
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