A NOVEL SYNTHESIS OF 3,4,5,6-TETRAHYDRO-7-HYDROXY-1H-AZEPINO[5,4,3-cd]INDOLE DERIVATIVES FROM SEROTONIN

被引：7

作者：

Yamada, Koji ^{[1
]}

Teranishi, Sakiko ^{[2
]}

Miyashita, Ayako ^{[2
]}

Ishikura, Minoru ^{[1
]}

Somei, Masanori ^{[2
]}

机构：

[1] Hlth Sci Univ Hokkaido, Fac Pharmaceut Sci, Ishikari, Hokkaido 0610293, Japan

[2] Kanazawa Univ, Fac Pharmaceut Sci, Grad Sch Nat Sci & Technol, Kanazawa, Ishikawa 9201192, Japan

来源：

HETEROCYCLES | 2011年 / 83卷 / 11期

关键词：

Ab-Acylserotonin; Ab-Alkylserotonin; 3,4,5,6-Tetrahydro-7-hydroxy-1H-azepino[5,4,3-cd]indole; 1H-Azepino[5,4,3-cd]indole-2-one; Serotonin; SHORT STEP SYNTHESIS; ERGOT ALKALOIDS; 1-HYDROXYINDOLE DERIVATIVES; BROMOMELATONIN DERIVATIVES; COMBATING DESERTIFICATION; PLATELET-AGGREGATION; BONE-DISEASES; CHEMISTRY; INDOLES; 1-HYDROXYTRYPTAMINES;

D O I：

10.3987/COM-11-12345

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Utilizing novel Nb-substituted serotonins, 5- and/or 6-substituted 3,4,5,6-tetrahydro-7-hydroxy-1H-azepino[5,4,3-cd]indole derivatives are produced simply by treating serotonins with aldehydes under basic conditions. Synthesis of 2,2a,3,4,5,6-hexahydro-7-hydroxy-1H-azepino[5,4,3-cd]indole-2-one derivatives is also reported.

引用

页码：2547 / 2562

页数：16

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