Streptozotocin-induced diabetes lowers retinol-binding protein and transthyretin concentrations in rats

被引：20

作者：

Tuitoek, PJ ^{[1
]}

Ritter, SJ ^{[1
]}

Smith, JE ^{[1
]}

Basu, TK ^{[1
]}

机构：

[1] PENN STATE UNIV,DEPT NUTR,UNIVERSITY PK,PA 16802

来源：

BRITISH JOURNAL OF NUTRITION | 1996年 / 76卷 / 06期

基金：

加拿大自然科学与工程研究理事会;

关键词：

streptozotocin; diabetes mellitus; retinol-binding protein; transthyretin; vitamin A;

D O I：

10.1079/BJN19960095

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Retinol-binding protein (RBP) and transthyretin (TTR) in the plasma, liver and kidney, retinol in plasma, and total vitamin A in the liver were measured in rats 6 weeks after diabetes mellitus had been induced by streptozotocin (STZ). The diabetic rats gained 83% less weight despite consuming 45% more feed than the non-diabetic controls. Plasma and kidney concentrations of RBP and TTR were significantly lower in diabetic than in the non-diabetic control rats. Unlike the retinol carrier proteins, plasma albumin concentrations remained unaffected. Plasma concentrations of retinol were decreased while its hepatic levels increased in the diabetic animals. The depressed circulatory levels of retinol may reflect an altered metabolism of its transport proteins.

引用

页码：891 / 897

页数：7

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