Human Biomarkers of Outcome Following Rift Valley Fever Virus Infection

被引：10
|
作者：
McElroy, Anita K. [1 ,2 ,3 ,4 ]
Harmon, Jessica R. [1 ]
Flietstra, Timothy [1 ]
Nichol, Stuart T. [1 ]
Spiropoulou, Christina F. [1 ]
机构：
[1] US Ctr Dis Control & Prevent, Viral Special Pathogens Branch, Atlanta, GA USA
[2] Emory Univ, Sch Med, Div Pediat Infect Dis, Atlanta, GA 30322 USA
[3] Childrens Healthcare Atlanta, Atlanta, GA USA
[4] Univ Pittsburgh, Sch Med, Div Pediat Infect Dis, Childrens Hosp Pittsburgh,Med Ctr, Pittsburgh, PA 15260 USA
来源：
JOURNAL OF INFECTIOUS DISEASES | 2018年 / 218卷 / 11期
基金：
美国国家卫生研究院;
关键词：
Rift Valley fever virus; biomarker; chemokine; inflammation; pathogenesis; CYTOKINE;
D O I：
10.1093/infdis/jiy393
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Rift Valley fever virus is an arbovirus found in Africa and the Middle East. Most infected individuals experience a mild self-limiting illness; however, some develop severe disease including hepatitis, hemorrhagic fever, or encephalitis. The biological reasons for these marked differences in disease manifestation are unknown. In this study, we evaluate 32 biomarkers in serum of 26 patients from an outbreak that occurred in Saudi Arabia in 2000-2001. Eleven biomarkers correlated with viral RNA. Thirteen biomarkers were associated with a fatal outcome. No associations of biomarkers and hemorrhage or central nervous system disease were identified in this cohort.
引用
收藏
页码：1847 / 1851
页数：5
相关论文
共 50 条
  • [41] Rift Valley fever virus: Unanswered questions
    Bird, Brian H.
    McElroy, Anita K.
    ANTIVIRAL RESEARCH, 2016, 132 : 274 - 280
  • [42] PATHOGENICITY OF RIFT VALLEY FEVER VIRUS FOR BABOON
    DAVIES, FG
    CLAUSEN, B
    LUND, LJ
    TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 1972, 66 (02) : 363 - &
  • [43] Rift Valley Fever Virus-Infection, Pathogenesis and Host Immune Responses
    Nair, Niranjana
    Osterhaus, Albert D. M. E.
    Rimmelzwaan, Guus F.
    Prajeeth, Chittappen Kandiyil
    PATHOGENS, 2023, 12 (09):
  • [44] Experimental Infection of Domestic Pigs (Sus scrofa) with Rift Valley Fever Virus
    Lubisi, Baratang Alison
    Mutowembwa, Paidamwoyo Barry
    Ndouvhada, Phumudzo Nomicia
    Odendaal, Lieza
    Bastos, Armanda D. S.
    Penrith, Mary-Louise
    VIRUSES-BASEL, 2023, 15 (02):
  • [45] Seroprevalence of Rift Valley fever virus infection in camels (dromedaries) in northern Tanzania
    Emmanuel Senyael Swai
    Calvin Sindato
    Tropical Animal Health and Production, 2015, 47 : 347 - 352
  • [46] RIFT VALLEY FEVER VIRUS CAUSES MISCARRIAGES
    不详
    TIJDSCHRIFT VOOR DIERGENEESKUNDE, 2016, 141 (11) : 5 - 5
  • [47] THE DEVELOPMENT OF NEUROTROPISM IN RIFT VALLEY FEVER VIRUS
    KITCHEN, SF
    ANNALS OF TROPICAL MEDICINE AND PARASITOLOGY, 1950, 44 (02): : 132 - 145
  • [48] PLAQUE FORMATION WITH RIFT VALLEY FEVER VIRUS
    TAKEMORI, N
    NAKANO, M
    HEMMI, M
    VIROLOGY, 1955, 1 (02) : 250 - 251
  • [49] Creation of a Nonspreading Rift Valley Fever Virus
    Kortekaas, Jeroen
    Oreshkova, Nadia
    Cobos-Jimenez, Viviana
    Vloet, Rianka P. M.
    Potgieter, Christiaan A.
    Moormann, Rob J. M.
    JOURNAL OF VIROLOGY, 2011, 85 (23) : 12622 - 12630
  • [50] RIFT VALLEY FEVER - TRANSMISSION OF THE VIRUS BY MOSQUITOES
    SMITHBURN, KC
    HADDOW, AJ
    LUMSDEN, WHR
    BRITISH JOURNAL OF EXPERIMENTAL PATHOLOGY, 1949, 30 (01): : 35 - 47
12345