Human Biomarkers of Outcome Following Rift Valley Fever Virus Infection

被引：10

作者：

McElroy, Anita K. ^{[1
,2
,3
,4
]}

Harmon, Jessica R. ^{[1
]}

Flietstra, Timothy ^{[1
]}

Nichol, Stuart T. ^{[1
]}

Spiropoulou, Christina F. ^{[1
]}

机构：

[1] US Ctr Dis Control & Prevent, Viral Special Pathogens Branch, Atlanta, GA USA

[2] Emory Univ, Sch Med, Div Pediat Infect Dis, Atlanta, GA 30322 USA

[3] Childrens Healthcare Atlanta, Atlanta, GA USA

[4] Univ Pittsburgh, Sch Med, Div Pediat Infect Dis, Childrens Hosp Pittsburgh,Med Ctr, Pittsburgh, PA 15260 USA

来源：

JOURNAL OF INFECTIOUS DISEASES | 2018年 / 218卷 / 11期

基金：

美国国家卫生研究院;

关键词：

Rift Valley fever virus; biomarker; chemokine; inflammation; pathogenesis; CYTOKINE;

D O I：

10.1093/infdis/jiy393

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Rift Valley fever virus is an arbovirus found in Africa and the Middle East. Most infected individuals experience a mild self-limiting illness; however, some develop severe disease including hepatitis, hemorrhagic fever, or encephalitis. The biological reasons for these marked differences in disease manifestation are unknown. In this study, we evaluate 32 biomarkers in serum of 26 patients from an outbreak that occurred in Saudi Arabia in 2000-2001. Eleven biomarkers correlated with viral RNA. Thirteen biomarkers were associated with a fatal outcome. No associations of biomarkers and hemorrhage or central nervous system disease were identified in this cohort.

引用

页码：1847 / 1851

页数：5

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