Identification and Quantification of Chloramphenicol in Medicines by Multisensory Digital Colorimetry

被引：1
|
作者：
Monogarova, O. V. [1 ]
Chaplenko, A. A. [1 ,2 ]
Oskolok, K. V. [1 ]
机构：
[1] Moscow MV Lomonosov State Univ, Dept Chem, Moscow 119991, Russia
[2] Minist Hlth Russian Federat, Sci Ctr Expert Evaluat Med Prod, Moscow 127051, Russia
来源：
MOSCOW UNIVERSITY CHEMISTRY BULLETIN | 2020年 / 75卷 / 01期
基金：
俄罗斯科学基金会;
关键词：
chloramphenicol; molecular sensor; digital colorimetry; drugs; SENSOR ARRAY;
D O I：
10.3103/S0027131420010071
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
An effective, affordable, and rapid method for the analysis of drugs based on chloramphenicol is developed using multisensory digital colorimetry. The use of a two-dimensional code for the identification and quantification of chloramphenicol with the minimum level of informational noise is proposed. The principal component analysis is used to increase the reliability of the results of the determination of the medicinal substance. The adequacy of the developed approach is confirmed by the analysis of chloramphenicol preparations in the form of two dosage forms: tablets and eye drops. The accuracy of the results is confirmed by the standard addition method. The results prove that the preparations do not have statistically significant differences from the values declared by the manufacturer.
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页码：1 / 7
页数：7
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