Genotoxicity and Antigenotoxicity of selected South African indigenous plants

被引：16
|
作者：
Makhuvele, R. [1 ,2 ]
Matshoga, R. G. [1 ]
Antonissen, R.
Pieters, L. [3 ]
Verschaeve, L. [4 ,5 ]
Elgorashi, E. E. [1 ,2 ]
机构：
[1] Agr Res Council Onderstepoort Vet Res, Publ Hlth & Zoonosis Programme, Toxicol & Ethnovet Med, Private Bag X05, ZA-0110 Onderstepoort, South Africa
[2] Univ Pretoria, Dept Paraclin Sci, Private Bag X04, ZA-0110 Onderstepoort, South Africa
[3] Univ Antwerp, Dept Pharmaceut Sci, B-2610 Antwerp, Belgium
[4] Sci Inst Publ Hlth, OD Publ Hlth & Surveillance, Lab Toxicol, Juliette Wytsmanstr 14, B-1050 Brussels, Belgium
[5] Univ Antwerp, Dept Biomed Sci, B-2610 Antwerp, Belgium
来源：
SOUTH AFRICAN JOURNAL OF BOTANY | 2018年 / 114卷
基金：
新加坡国家研究基金会;
关键词：
Genotoxicity; Antigenotoxicity; Aflatoxin B-1; Vitotox assay; Ames assay; Plant extracts; HEPATOCELLULAR-CARCINOMA; ANTIMUTAGENICITY; MUTAGENICITY; MYCOTOXINS; TOXICITY; EXTRACTS;
D O I：
10.1016/j.sajb.2017.10.016
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Twenty-two plant species extracted with dichloromethane and 90% methanol were investigated for their genotoxicity as well as antigenotoxicity against aflatoxin B-1 induced-mutagenicity using the Ames (Salmonella typhimurium strains TA98 and TA100) and Vitotox assays in the presence of S9 rat liver fraction. The results obtained from Ames assay for some plant extracts correlated well with the results obtained from the Vitotox assay. Dichloromethane and methanolic extracts of Helichrysum petiolare, Protea hybrid, Protea roupelliae, Artabotrys brachypetalus (leaves), Friesodielsia obovata, Hexalobus monopetalus, Monanthotaxis caffra, Monodora junodis, Uvaria caffra, Xylopia parviflora, Podocarpus henkellii, Rhoicissus sekhukhuniensis, Podocarpus elongatus and Agapanthus praecox had moderate to strong antimutagenic activities in both Ames and Vitotox assays. The methanolic extract of Annona senegalensis and dichloromethane extract of Podocarpus falcutus also showed antigenotoxic potentials against aflatoxin B-1 induced mutagenicity. Methanolic extracts of Xylopia sp., showed a co-mutagenic effect with aflatoxin B-1 in the Ames assay (strain TA100). All extracts were not genotoxic in the Vitotox assay in the absence of S9. Plant extracts with promising antimutagenic effects could be used in the form of feed and food supplements as a preventative strategy against aflatoxin B-1 induced mutagenicity and carcinogenicity. (c) 2017 SAAB. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码：89 / 99
页数：11
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