Synthesis and characterization of biodegradable amphiphilic triblock copolymers methoxy-poly(ethylene glycol)-b-poly (L-lysine)-b-poly(L-lactic acid)

被引:15
|
作者
Zhu, Ming-Qiang [1 ,2 ]
Xiang, Li [1 ]
Yang, Ke [1 ]
Shen, Lin-Jing [1 ]
Long, Feng [1 ]
Fan, Jun-Bing [1 ]
Yi, Hu-Qiang [1 ]
Xiang, Jiannan [1 ]
Aldred, Matthew P. [2 ]
机构
[1] Hunan Univ, Coll Chem & Chem Engn, State Key Lab Chemo Biosensing & Chemometr, Changsha 410082, Peoples R China
[2] Huazhong Univ Sci & Technol, Wuhan Natl Lab Optoelect, Wuhan 430074, Hubei, Peoples R China
关键词
Poly(ethylene glycol)-b-poly(L-lysine)-b-poly (L-lactic acid); Poly(ethylene glycol)-b-poly (N-epsilon-benzyloxycarbonyl -L-lysine)-b-poly(L-lactic acid); Triblock copolymer; Poly(ethylene glycol); Poly(L-lactic acid); Poly(L-lysine); Lys(Z)-NCA; Cell-cytotoxicity; POLY(ETHYLENE GLYCOL); BLOCK-COPOLYMERS; MICELLES; DELIVERY; POLYMERIZATION; VESICLES; DRUG; GLYCOL)-B-POLY(L-LACTIDE)-B-POLY(L-LYSINE); BIOMATERIALS; ATTACHMENT;
D O I
10.1007/s10965-011-9808-y
中图分类号
O63 [高分子化学(高聚物)];
学科分类号
070305 ; 080501 ; 081704 ;
摘要
Starting from MPEG-NH2, a series of amphiphilic triblock copolymers MPEG-b-PLL-b-PLA were synthesized through PEG-NH2-initiated ring-open polymerization of N-epsilon-benzyloxycarbonyl-L-lysine, followed by acylation coupling between the amino-terminated MPEG-b-PZLL-NH2 and carboxyl-terminal PLA and the deprotection of amines. The block copolymers were characterized by FT-IR, H-1 NMR, GPC, DSC and TEM. The copolymer functional groups, molecular and block structures were verified by FT-IR, H-1 NMR and DSC, respectively. The GPC results indicate that the chain lengths of each block can be controlled by varying the feed ratios of the monomer and initiator, providing the polymer samples with a narrow molecular weight distribution (M-w/M-n = 1.10-1.25). The TEM analysis shows that the triblock polymers can self-assemble into polymeric micelles in aqueous solution with spherical morphology. The cell-cytotoxicity assay indicates that the triblock polymers show no obvious cytotoxicity against Bel7402 human hepatoma cells.
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页数:11
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