Starting from MPEG-NH2, a series of amphiphilic triblock copolymers MPEG-b-PLL-b-PLA were synthesized through PEG-NH2-initiated ring-open polymerization of N-epsilon-benzyloxycarbonyl-L-lysine, followed by acylation coupling between the amino-terminated MPEG-b-PZLL-NH2 and carboxyl-terminal PLA and the deprotection of amines. The block copolymers were characterized by FT-IR, H-1 NMR, GPC, DSC and TEM. The copolymer functional groups, molecular and block structures were verified by FT-IR, H-1 NMR and DSC, respectively. The GPC results indicate that the chain lengths of each block can be controlled by varying the feed ratios of the monomer and initiator, providing the polymer samples with a narrow molecular weight distribution (M-w/M-n = 1.10-1.25). The TEM analysis shows that the triblock polymers can self-assemble into polymeric micelles in aqueous solution with spherical morphology. The cell-cytotoxicity assay indicates that the triblock polymers show no obvious cytotoxicity against Bel7402 human hepatoma cells.
机构:
Tokyo Univ Agr & Technol, Grad Sch Bioapplicat & Syst Engn, Koganei, Tokyo 1848588, JapanTokyo Univ Agr & Technol, Grad Sch Bioapplicat & Syst Engn, Koganei, Tokyo 1848588, Japan
Fujioka, Masahiro
Sato, Hisaya
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Tokyo Univ Agr & Technol, Grad Sch Bioapplicat & Syst Engn, Koganei, Tokyo 1848588, JapanTokyo Univ Agr & Technol, Grad Sch Bioapplicat & Syst Engn, Koganei, Tokyo 1848588, Japan
Sato, Hisaya
Tsuchiya, Kousuke
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Tokyo Univ Agr & Technol, Grad Sch Bioapplicat & Syst Engn, Koganei, Tokyo 1848588, JapanTokyo Univ Agr & Technol, Grad Sch Bioapplicat & Syst Engn, Koganei, Tokyo 1848588, Japan
Tsuchiya, Kousuke
Ogino, Kenji
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Tokyo Univ Agr & Technol, Grad Sch Bioapplicat & Syst Engn, Koganei, Tokyo 1848588, JapanTokyo Univ Agr & Technol, Grad Sch Bioapplicat & Syst Engn, Koganei, Tokyo 1848588, Japan
机构:
Univ Utah, Dept Pharmaceut & Pharmaceut Chem, Salt Lake City, UT 84108 USAUniv Utah, Dept Pharmaceut & Pharmaceut Chem, Salt Lake City, UT 84108 USA
Lee, Eun Seong
Oh, Kyung Taek
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Univ Utah, Dept Pharmaceut & Pharmaceut Chem, Salt Lake City, UT 84108 USAUniv Utah, Dept Pharmaceut & Pharmaceut Chem, Salt Lake City, UT 84108 USA
Oh, Kyung Taek
Kim, Dongin
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Univ Utah, Dept Pharmaceut & Pharmaceut Chem, Salt Lake City, UT 84108 USAUniv Utah, Dept Pharmaceut & Pharmaceut Chem, Salt Lake City, UT 84108 USA
Kim, Dongin
Youn, Yu Seok
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Univ Utah, Dept Pharmaceut & Pharmaceut Chem, Salt Lake City, UT 84108 USAUniv Utah, Dept Pharmaceut & Pharmaceut Chem, Salt Lake City, UT 84108 USA
Youn, Yu Seok
Bae, You Han
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Univ Utah, Dept Pharmaceut & Pharmaceut Chem, Salt Lake City, UT 84108 USAUniv Utah, Dept Pharmaceut & Pharmaceut Chem, Salt Lake City, UT 84108 USA
机构:
Sichuan Univ, Natl Engn Res Ctr Biomat, Chengdu 610064, Peoples R China
Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R ChinaSichuan Univ, Natl Engn Res Ctr Biomat, Chengdu 610064, Peoples R China
Liu, Rong
He, Bin
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Sichuan Univ, Natl Engn Res Ctr Biomat, Chengdu 610064, Peoples R ChinaSichuan Univ, Natl Engn Res Ctr Biomat, Chengdu 610064, Peoples R China
He, Bin
Li, Dong
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Sichuan Univ, Natl Engn Res Ctr Biomat, Chengdu 610064, Peoples R ChinaSichuan Univ, Natl Engn Res Ctr Biomat, Chengdu 610064, Peoples R China
Li, Dong
Lai, Yusi
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Sichuan Univ, Natl Engn Res Ctr Biomat, Chengdu 610064, Peoples R ChinaSichuan Univ, Natl Engn Res Ctr Biomat, Chengdu 610064, Peoples R China
Lai, Yusi
Tang, James Z.
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Wolverhampton Univ, Sch Appl Sci, Dept Pharm, Wolverhampton WV1 1SB, EnglandSichuan Univ, Natl Engn Res Ctr Biomat, Chengdu 610064, Peoples R China
Tang, James Z.
Gu, Zhongwei
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Sichuan Univ, Natl Engn Res Ctr Biomat, Chengdu 610064, Peoples R ChinaSichuan Univ, Natl Engn Res Ctr Biomat, Chengdu 610064, Peoples R China
机构:
Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Chem & Phys, Changchun 130022, Peoples R China
Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R ChinaChinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Chem & Phys, Changchun 130022, Peoples R China
Zhao Changwen
Zhuang Xiuli
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Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Chem & Phys, Changchun 130022, Peoples R ChinaChinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Chem & Phys, Changchun 130022, Peoples R China
Zhuang Xiuli
Chen Xuesi
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Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Chem & Phys, Changchun 130022, Peoples R ChinaChinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Chem & Phys, Changchun 130022, Peoples R China
Chen Xuesi
Jing Xiabin
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Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Chem & Phys, Changchun 130022, Peoples R ChinaChinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Chem & Phys, Changchun 130022, Peoples R China