IL-10 Producing Regulatory B Cells in Mice and Humans: State of the Art

被引：0
|
作者：
Bouaziz, J. -D. [1 ,2 ,3 ]
Le Buanec, H. [1 ,2 ]
Saussine, A. [1 ,2 ]
Bensussan, A. [1 ,2 ]
Bagot, M. [1 ,2 ]
机构：
[1] INSERM, U976, F-75475 Paris, France
[2] Univ Paris Diderot, Lab Immunol Dermatol & Oncol, UMR S 976, F-75475 Paris, France
[3] Hop St Louis, INSERM, U976, Serv Dermatol, F-75010 Paris, France
来源：
CURRENT MOLECULAR MEDICINE | 2012年 / 12卷 / 05期
关键词：
B cell; interleukin; 10; tolerance; SYSTEMIC-LUPUS-ERYTHEMATOSUS; COLLAGEN-INDUCED ARTHRITIS; TUMOR-NECROSIS-FACTOR; T-CELLS; AUTOIMMUNE ENCEPHALOMYELITIS; HUMAN MONOCYTES; B10; CELLS; RECEPTOR EXPRESSION; SUPPRESSIVE ROLE; INTERLEUKIN-10;
D O I：
暂无
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
IL-10-producing regulatory B cells have been undoubtedly identified in mice and shown to down-regulate inflammation, making them potentially important for maintenance of tolerance. Several recent works have also identified IL-10 producing regulatory B cells in humans and have begun to unravel their phenotype and mode of suppression. Cell surface phenotype of human Bregs includes CD38, CD27, CD24 and CD5. Mechanisms of suppression may imply inhibition of CD4(+) T proliferation, inhibition of Th1 differentiation, induction of regulatory T cells and suppression of monocytes activation. These recent findings imply that manipulating IL-10 production by human B cells could be a useful therapeutic strategy for modulating immune responses in humans.
引用
收藏
页码：519 / 527
页数：9
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