Fluorescent Probes for the Detection of Hydrogen Sulfide in Biological Systems

被引：274
|
作者：
Xuan, Weimin [2 ]
Sheng, Chunquan [1 ]
Cao, Yanting [2 ]
He, Wenhan [2 ]
Wang, Wei [2 ,3 ]
机构：
[1] Second Mil Med Univ, Sch Pharm, Dept Med Chem, Shanghai 200433, Peoples R China
[2] Univ New Mexico, Dept Chem & Chem Biol, Albuquerque, NM 87131 USA
[3] E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2012年 / 51卷 / 10期
基金：
美国国家科学基金会;
关键词：
azides; fluorescein; fluorescent probes; hydrogen sulfide; rhodamines; ION CHROMATOGRAPHY; BRAIN-TISSUE; 3RD GAS; H2S; CONSUMPTION; MEDIATOR; BLOOD; CELLS; STATE;
D O I：
10.1002/anie.201107025
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Detective work: Three highly sensitive and selective fluorescent probes for the detection of H2S have been developed. Two of the probes detect H2S by the reduction of an azide moiety to an amine group, which changes the probes into their fluorescent forms and generates a fluorescent signal. In the third method, the fluorescent signal is created by using H 2S as a nucleophile in a reaction that unmasks fluorescein. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：2282 / 2284
页数：3
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