Human Polyomavirus 7-Associated Pruritic Rash and Viremia in Transplant Recipients

被引：78

作者：

Ho, Jonhan ^{[1
]}

Jedrych, Jaroslaw J. ^{[1
]}

Feng, Huichen ^{[5
]}

Natalie, August A. ^{[1
]}

Grandinetti, Lisa ^{[1
]}

Mirvish, Ezra ^{[1
]}

Crespo, Maria M. ^{[2
]}

Yadav, Dhiraj ^{[3
]}

Fasanella, Kenneth E. ^{[3
]}

Proksell, Siobhan ^{[3
]}

Kuan, Shih-Fan ^{[4
]}

Pastrana, Diana V. ^{[6
]}

Buck, Christopher B. ^{[6
]}

Shuda, Yoko ^{[5
]}

Moore, Patrick S. ^{[5
]}

Chang, Yuan ^{[5
]}

机构：

[1] Univ Pittsburgh, Sch Med, Dept Dermatol, Pittsburgh, PA 15213 USA

[2] Univ Pittsburgh, Sch Med, Div Pulm Allergy & Crit Care, Pittsburgh, PA 15213 USA

[3] Univ Pittsburgh, Sch Med, Dept Med, Pittsburgh, PA 15213 USA

[4] Univ Pittsburgh, Sch Med, Dept Pathol, Pittsburgh, PA 15213 USA

[5] Univ Pittsburgh, Inst Canc, Canc Virol Program, Pittsburgh, PA 15213 USA

[6] NCI, Cellular Oncol Lab, NIH, Bethesda, MD 20892 USA

来源：

JOURNAL OF INFECTIOUS DISEASES | 2015年 / 211卷 / 10期

基金：

美国国家卫生研究院;

关键词：

polyomavirus; HPyV7; skin viral infection; transplantation-associated disease; immunosuppression; MERKEL CELL POLYOMAVIRUS; CARCINOMA; EXPRESSION; ANTIGENS;

D O I：

10.1093/infdis/jiu524

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Human polyomavirus 7 (HPyV7) is one of 11 HPyVs recently discovered through genomic sequencing technologies. Two lung transplant recipients receiving immunosuppressive therapy developed pruritic, brown plaques on the trunk and extremities showing a distinctive epidermal hyperplasia with virus-laden keratinocytes containing densely packed 36-45-nm icosahedral capsids. Rolling circle amplification and gradient centrifugation testing were positive for encapsidated HPyV7 DNA in skin and peripheral blood specimens from both patients, and HPyV7 early and capsid proteins were abundantly expressed in affected tissues. We describe for the first time that HPyV7 is associated with novel pathogenicity in some immunosuppressed individuals.

引用

页码：1560 / 1565

页数：6

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