High-dose treatment with autologous stem cell transplantation versus sequential chemotherapy: the GELA experience

被引：0
|
作者：
Bosly, A [1 ]
Haioun, C
Gisselbrecht, C
Reyes, F
Coiffier, B
机构：
[1] Mt Godinne Univ Hosp, Dept Hematol, B-5530 Yvoir, Belgium
[2] Hop St Louis, Paris, France
[3] Hop Henri Mondor, F-94010 Creteil, France
[4] Ctr Hosp Lyon Sud, Lyon, France
来源：
EUROPEAN JOURNAL OF HAEMATOLOGY | 2001年 / 66卷
关键词：
non-Hodgkin's lymphoma; sequential chemotherapy; intensive treatment; autologous stem cell transplantation; relapsing/refractory; stem cell factor;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Autologous stem-cell transplantation (ASCT) has permitted to deliver high-dose therapy (HDT). In aggressive lymphomas, the GELA group conducted prospective and retrospective studies comparing HDT + ASCT to conventional sequential chemotherapy. In relapsing patients and in partial remission, retrospective studies showed a survival advantage for HDT + ASCT over sequential chemotherapy. In complete response, advantage for HDT + ASCT was demonstrated in a prospective trial only for patients with high intermediate or high risk in the IPI score. The attainment of a maximal reduction of the tumoral mass before going HDT is very important either in first line or in relapsing patients.
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页码：3 / 7
页数：5
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