Treatment of fibrotic interstitial lung disease: current approaches and future directions

被引：47

作者：

Johannson, Kerri A. ^{[1
]}

Chaudhuri, Nazia ^{[2
,3
]}

Adegunsoye, Ayodeji ^{[4
]}

Wolters, Paul J. ^{[5
]}

机构：

[1] Univ Calgary, Snyder Inst Chron Dis, Dept Med & Community Hlth Sci, Calgary, AB, Canada

[2] Manchester Univ NHS Fdn Trust, Wythenshawe Hosp, North West Lung Ctr, Manchester, Lancs, England

[3] Univ Manchester, Div Infect Immun & Resp Med, Manchester, Lancs, England

[4] Univ Chicago, Sect Pulm & Crit Care Med, Chicago, IL 60637 USA

[5] Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA

来源：

LANCET | 2021年 / 398卷 / 10309期

基金：

美国国家卫生研究院;

关键词：

IDIOPATHIC PULMONARY-FIBROSIS; DOUBLE-BLIND; SYSTEMIC-SCLEROSIS; MYCOPHENOLATE-MOFETIL; CONTROLLED-TRIAL; PALLIATIVE CARE; CHRONIC COUGH; PLACEBO; PIRFENIDONE; SAFETY;

D O I：

10.1016/S0140-6736(21)01826-2

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Fibrotic interstitial lung disease (ILD) represents a large group of pulmonary disorders that are often progressive and associated with high morbidity and early mortality. Important advancements in the past 10 years have enabled a better understanding, characterisation, and treatment of these diseases. This Series paper summarises the current approach to treatment of fibrotic ILDs, both pharmacological and non-pharmacological, including recent discoveries and practice-changing clinical trials. We further outline controversies and challenges, with discussion of evolving concepts and future research directions.

引用

页码：1450 / 1460

页数：11

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