Physiochemical Properties of the Complex of Myricetin and Hydroxypropyl-β-Cyclodextrin

被引：7
|
作者：
Nan, Haijuan [1 ]
Ma, Hanjun [1 ]
Zhang, Ruiting [1 ]
Zhan, Rui [1 ]
机构：
[1] Henan Inst Sci & Technol, Sch Food Sci, Xinxiang 453003, Peoples R China
来源：
TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH | 2014年 / 13卷 / 11期
关键词：
Myricetin; Hydroxypropyl-beta-cyclodextrin; Complexation; Physicochemical properties;
D O I：
10.4314/tjpr.v13i11.3
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Purpose: To improve the hydrophilic property of myricetin by complexing it with hydroxypropyl-beta-cyclodextrin (HP-beta-CD) Methods: The complexes of myricetin and HP-beta-CD were prepared in both water and ethanol. The physicochemical properties of the complex were investigated by ultraviolet-visible spectrometry (UV), Fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), differential scanning calorimetry (DSC) and x-ray diffractometry (XRD). Results: The content of myricetin in the complex prepared in ethanol (3.71 %) was higher than that prepared in water (1.43 %). Characterization studies indicate that myricetin in the complex was molecularly dispersed in HP-beta-CD matrix. Conclusion: Ethanol is the better solvent to prepare the complex of myricetin and hydroxypropyl-beta-cyclodextrin. Myricetin and HP-beta-CD in the complex are combined by non-covalent bond, and thus did not form a new compound.
引用
收藏
页码：1791 / 1796
页数：6
相关论文
共 50 条
  • [1] Development of a myricetin/hydroxypropyl-β-cyclodextrin inclusion complex: Preparation, characterization, and evaluation
    Yao, Yashu
    Xie, Yan
    Hong, Chao
    Li, Guowen
    Shen, Hongyi
    Ji, Guang
    [J]. CARBOHYDRATE POLYMERS, 2014, 110 : 329 - 337
  • [2] Preparation and Physicochemical Properties of the Complex of Naringenin with Hydroxypropyl-β-Cyclodextrin
    Wen, Jiping
    Liu, Benguo
    Yuan, Erdong
    Ma, Yuxiang
    Zhu, Yongyi
    [J]. MOLECULES, 2010, 15 (06): : 4401 - 4407
  • [3] Inclusion Complex of Paclitaxel in Hydroxypropyl-β-cyclodextrin
    CHEN Yue 1
    2. Institute of Frontier Medical Science
    3. Center of Drug Discovery
    [J]. Chemical Research in Chinese Universities, 2005, (06) : 749 - 752
  • [4] Inclusion complex of paclitaxel in hydroxypropyl-β-cyclodextrin
    Chen, Y
    Zhou, YL
    Ren, Y
    Yan, WQ
    [J]. CHEMICAL RESEARCH IN CHINESE UNIVERSITIES, 2005, 21 (06) : 749 - 752
  • [5] Inclusion Complex of Carprofen with Hydroxypropyl-β-cyclodextrin
    Fu-An Chen
    An-Bang Wu
    Chau-Yang Chen
    [J]. Journal of inclusion phenomena and macrocyclic chemistry, 2003, 46 : 111 - 115
  • [6] Inclusion complex of carprofen with hydroxypropyl-β-cyclodextrin
    Chen, FA
    Wu, AB
    Chen, CY
    [J]. JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY, 2003, 46 (1-2) : 111 - 115
  • [7] Study on the properties of an inclusion complex of hydroxypropyl-β-cyclodextrin and benzyl isothiocyanates
    [J]. Zhu, Hua-Ping, 1600, South China University of Technology (30):
  • [8] Preparation and Characterization of a Complex of Paeonol and Hydroxypropyl-β-cyclodextrin
    Chen, Chungang
    Xu, Xinjuan
    Li, Yaoran
    Ma, Hanjun
    [J]. TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH, 2015, 14 (09) : 1565 - 1571
  • [9] Characterization of the inclusion complex of zerumbone with hydroxypropyl-β-cyclodextrin
    Eid, Eltayeb E. M.
    Abdul, Ahmad Bustamam
    Suliman, Fakhr Eldin O.
    Sukari, Mohd A.
    Rasedee, A.
    Fatah, Safa S.
    [J]. CARBOHYDRATE POLYMERS, 2011, 83 (04) : 1707 - 1714
  • [10] Sulfamethoxazole/hydroxypropyl-β-cyclodextrin complex: preparation and characterization
    Garnero, Claudia
    Aiassa, Virginia
    Longhi, Marcela
    [J]. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2012, 63 : 74 - 79
12345