Preparation and Characterization of a Complex of Paeonol and Hydroxypropyl-β-cyclodextrin

被引：1
|
作者：
Chen, Chungang [1 ]
Xu, Xinjuan [2 ]
Li, Yaoran [1 ]
Ma, Hanjun [1 ]
机构：
[1] Henan Inst Sci & Technol, Sch Food Sci, Xinxiang 453003, Peoples R China
[2] Henan Inst Sci & Technol, Sch Life Sci & Technol, Xinxiang 453003, Peoples R China
来源：
TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH | 2015年 / 14卷 / 09期
关键词：
Paeonol; Hydroxypropyl-beta-cyclodextrin; Complexation; Aqueous solubility; Heat stability; EXPRESSION;
D O I：
10.4314/tjpr.v14i9.4
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Purpose: To improve the solubility of paeonol in water by complexing with hydroxypropyl-beta-cyclodextrin (HP-beta-CD) and also to characterize the physicochemical properties of the complex. Methods: The complex of paeonol and HP-beta-CD was prepared by freeze-drying method. Its physicochemical properties were studied by phase-solubility method, ultraviolet-visible spectrometry (UV), infrared spectrometry (IR), scanning electron microscopy (SEM), x-ray diffractometry (XRD) and thermogravimetric/differential scanning calorimetry (TG/DSC). Results: The phase-solubility results showed that paeonol formed a 1:1 stoichiometric complex with HP-beta-CD while UV and IR spectra suggested that HP-beta-CD and paeonol in the complex interacted by a non-covalent bond. SEM and XRD indicate that the heat stability of paeonol was significantly improved by complexing with HP-beta-CD. Conclusion: Paeonol can be efficiently complexed with HP-beta-CD to form a complex by freeze-drying method. The aqueous solubility and heat stability of paeonol is significantly improved by complexation HP-beta-CD.
引用
收藏
页码：1565 / 1571
页数：7
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