The Ubiquitin System: An Emerging Therapeutic Target for Lung Cancer

被引:25
|
作者
Jin, Jun-O [1 ,2 ,3 ]
Puranik, Nidhi [4 ]
Bui, Quyen Thu [5 ]
Yadav, Dhananjay [3 ]
Lee, Peter Chang-Whan [5 ]
机构
[1] Fudan Univ, Shanghai Med Coll, Shanghai Publ Hlth Clin Ctr, Shanghai 201508, Peoples R China
[2] Fudan Univ, Shanghai Med Coll, Inst Biomed Sci, Shanghai 201508, Peoples R China
[3] Yeungnam Univ, Dept Med Biotechnol, Gyongsan 38541, South Korea
[4] Bharathiar Univ, Biol Sci Dept, Coimbatore 641046, Tamil Nadu, India
[5] Univ Ulsan, Dept Biomed Sci, Asan Med Ctr, Coll Med, Seoul 05505, South Korea
基金
新加坡国家研究基金会;
关键词
lung cancer; ubiquitin; ubiquitination; E3; ligase; cell signaling; deubiquitination; DEUBIQUITINATING ENZYME USP28; PROTEIN LIGASE; C-MYC; CELL-PROLIFERATION; MDM2; INHIBITOR; LENALIDOMIDE; PROTEASOME; EXPRESSION; DEGRADATION; RESISTANCE;
D O I
10.3390/ijms22179629
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The ubiquitin system, present in all eukaryotes, contributes to regulating multiple types of cellular protein processes such as cell signaling, cell cycle, and receptor trafficking, and it affects the immune response. In most types of cancer, unusual events in ubiquitin-mediated signaling pathway modulation can lead to a variety of clinical outcomes, including tumor formation and metastasis. Similarly, ubiquitination acts as a core component, which contributes to the alteration of cell signaling activity, dictating biosignal turnover and protein fates. As lung cancer acquires the most commonly mutated proteins, changes in the ubiquitination of the proteins contribute to the development of lung cancer. Various inhibitors targeting the ubiquitin system have been developed for clinical applications in lung cancer treatment. In this review, we summarize the current research advances in therapeutics for lung cancer by targeting the ubiquitin system.
引用
收藏
页数:14
相关论文
共 50 条
  • [21] Monoamine oxidase A: An emerging therapeutic target in prostate cancer
    Chen, Chia-Hui
    Wu, Boyang Jason
    FRONTIERS IN ONCOLOGY, 2023, 13
  • [22] DNA-PK as an Emerging Therapeutic Target in Cancer
    Mohiuddin, Ismail S.
    Kang, Min H.
    FRONTIERS IN ONCOLOGY, 2019, 9
  • [23] Neutrophils as an emerging therapeutic target and tool for cancer therapy
    Subhan, Md Abdus
    Torchilin, Vladimir P.
    LIFE SCIENCES, 2021, 285
  • [24] MicroRNA-124: An emerging therapeutic target in cancer
    Jia, Xinqi
    Wang, Xu
    Guo, Xiaorong
    Ji, Jingjing
    Lou, Ge
    Zhao, Junjie
    Zhou, Wenjia
    Guo, Mian
    Zhang, Maomao
    Li, Chao
    Tai, Sheng
    Yu, Shan
    CANCER MEDICINE, 2019, 8 (12): : 5638 - 5650
  • [25] CDK12: an emerging therapeutic target for cancer
    Lui, Goldie Y. L.
    Grandori, Carla
    Kemp, Christopher J.
    JOURNAL OF CLINICAL PATHOLOGY, 2018, 71 (11) : 957 - 962
  • [26] Notch signaling: An emerging therapeutic target for cancer treatment
    Yuan, Xun
    Wu, Hua
    Xu, Hanxiao
    Xiong, Huihua
    Chu, Qian
    Yu, Shiying
    Wu, Gen Sheng
    Wu, Kongming
    CANCER LETTERS, 2015, 369 (01) : 20 - 27
  • [27] The neurosteroid system: an emerging therapeutic target for hepatic encephalopathy
    Samir Ahboucha
    Roger F. Butterworth
    Metabolic Brain Disease, 2007, 22 : 291 - 308
  • [28] The neurosteroid system: an emerging therapeutic target for hepatic encephalopathy
    Ahboucha, Samir
    Butterworth, Roger F.
    METABOLIC BRAIN DISEASE, 2007, 22 (3-4) : 291 - 308
  • [29] Is loss of MGMT a therapeutic target in lung cancer
    Do, Hongdo
    Mitchell, Paul
    Dobrovic, Alexander
    CANCER RESEARCH, 2014, 74 (19)
  • [30] IS LOSS OF MGMT A THERAPEUTIC TARGET IN LUNG CANCER?
    Do, Hongdo
    Mitchell, Paul
    John, Thomas
    Murone, Carmel
    Solomon, Benjamin
    Dobrovic, Alexander
    JOURNAL OF THORACIC ONCOLOGY, 2013, 8 : S1172 - S1172