Severe infections in a cohort of patients with systemic lupus erythematosus

被引：6

作者：

Gonzalez Leon, Rocio ^{[1
]}

Castillo Palma, Maria Jesus ^{[1
]}

Garcia Hernandez, Francisco Jose ^{[1
]}

Sanchez Roman, Julio ^{[1
]}

机构：

[1] Hosp Univ Virgen del Rocio, Med Interna Serv, Unidad Colagenosis & Hipertens Pulmonar, Seville, Spain

来源：

MEDICINA CLINICA | 2010年 / 135卷 / 08期

关键词：

Systemic lupus erythematosus; Infections; Autoimmunity; RISK-FACTORS; SLE;

D O I：

10.1016/j.medcli.2010.03.026

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background and objective: To study severe infectious complications in a cohort of patients with systemic lupus erythematosus (SLE). Patients and method: Retrospective study of 705 patients followed from January 1980 to January 2008. Data are expressed in percentages. Results: The frequency of severe infectious was 38,6%. The etiology was bacterial 54,4%, viric 30,4% and opportunist in 15,2% patients. Involved organs were: Lung 38,2%, kidney 48,9%, central nervous system 43%. 43,75% patients received pulsed ciclofosfamide therapy and 88,6% received glucocorticoids (39,7% pulsed). The mortality was 27,7%. Conclusions: At present, infection is an important cause of mortality in patients with SLE. Early diagnosis of infectious complications is very important in SLE. (C) 2009 Elsevier Espana, S.L. All rights reserved.

引用

页码：365 / 367

页数：3

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