Implication of a Genetic Variant at PICALM in Alzheimer's Disease Patients and Centenarians

被引：16

作者：

Piaceri, Irene ^{[1
,2
]}

Bagnoli, Silvia ^{[1
,2
]}

Lucenteforte, Ersilia ^{[3
]}

Mancuso, Michelangelo ^{[4
]}

Tedde, Andrea ^{[1
,2
]}

Siciliano, Gabriele ^{[4
]}

Piacentini, Silvia ^{[1
,2
]}

Bracco, Laura ^{[1
,2
]}

Sorbi, Sandro ^{[1
,2
]}

Nacmias, Benedetta ^{[1
,2
]}

机构：

[1] Univ Florence, Dept Neurol & Psychiat Sci, I-50134 Florence, Italy

[2] Univ Florence, Ctr Ric Trasferimento & Alta Formaz DENOTHE, I-50134 Florence, Italy

[3] Univ Florence, Dept Preclin & Clin Pharmacol, I-50134 Florence, Italy

[4] Univ Pisa, Dept Neurosci, Neurol Clin, Pisa, Italy

来源：

JOURNAL OF ALZHEIMERS DISEASE | 2011年 / 24卷 / 03期

关键词：

Alzheimer's disease; apolipoprotein E; centenarian; genetic variation; PICALM; GENOME-WIDE ASSOCIATION; IDENTIFIES VARIANTS; CLU; CR-1; LONGEVITY; PROTEIN; CALM; LOCI;

D O I：

10.3233/JAD-2011-101791

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

A common polymorphism (rs3851179) in the PICALM (phosphatidylinositol-binding clathrin assembly protein) gene has been recently associated with reduced risk of developing late-onset Alzheimer's disease (LOAD). We analyzed the genotype and allele distributions of the PICALM polymorphism in 813 Italian subjects, including LOAD patients and centenarians. The segregation of the PICALM rs3851179 showed no statistically significant difference between LOAD cases and controls. The implication of a genetic variant at PICALM is confirmed for the first time, in centenarians, thus suggesting a possible role in longevity.

引用

页码：409 / 413

页数：5

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