Genetic variation in PICALM and Alzheimer's disease risk in Han Chinese

被引:4
|
作者
Jiang, Teng [1 ]
Yu, Jin-Tai [1 ,2 ,3 ]
Tan, Meng-Shan [3 ]
Wang, Hui-Fu [1 ]
Wang, Ying-Li [2 ]
Zhu, Xi-Chen [1 ]
Zhang, Wei [2 ]
Tan, Lan [1 ,2 ,3 ]
机构
[1] Nanjing Med Univ, Qingdao Municipal Hosp, Dept Neurol, Nanjing, Jiangsu, Peoples R China
[2] Qingdao Univ, Dept Neurol, Qingdao Municipal Hosp, Sch Med, Qingdao 266071, Peoples R China
[3] Ocean Univ China, Dept Neurol, Qingdao Municipal Hosp, Coll Med & Pharmaceut, Qingdao, Shandong, Peoples R China
基金
中国国家自然科学基金;
关键词
Alzheimer's disease; PICALM; Polymorphism; Association; GENOME-WIDE ASSOCIATION; IDENTIFIES VARIANTS; CR-1; CLU; POLYMORPHISMS; LOCI;
D O I
10.1016/j.neurobiolaging.2013.09.014
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
The current study was conducted to investigate the association of phosphatidylinositol-binding clathrin assembly protein gene (PICALM) with late-onset Alzheimer's disease (LOAD) risk in Han Chinese. We first sequenced PICALM for variants in a small sample (n = 100), and the selected variants were then genotyped in a larger cohort (n = 2292). Sequencing analysis identified 16 variants within PICALM including 5 new variants with extreme low frequency in the northern Han Chinese population. However, in the subsequent genotyping, none showed a significant association with LOAD risk after Bonferroni correction. These findings implicate that PICALM might not play a major role in the genetic predisposition to LOAD in Han Chinese. (C) 2014 Elsevier Inc. All rights reserved.
引用
收藏
页码:934.e1 / 934.e3
页数:3
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