Quantification of airway thickness changes in smoke-inhalation injury using in-vivo 3-D endoscopic frequency-domain optical coherence tomography

被引：23

作者：

Lee, Sang-Won ^{[1
]}

Heidari, Andrew E. ^{[2
]}

Yoon, David ^{[1
]}

Mukai, David ^{[1
]}

Ramalingam, Tirunelveli ^{[2
]}

Mahon, Sari ^{[1
]}

Yin, Jiechen ^{[3
]}

Jing, Joseph ^{[3
]}

Liu, Gangjun ^{[1
]}

Chen, Zhongping ^{[1
,3
]}

Brenner, Matthew ^{[1
,4
]}

机构：

[1] Univ Calif Irvine, Beckman Laser Inst, Irvine, CA 92612 USA

[2] OCT Med Imaging Inc, Irvine, CA 92612 USA

[3] Univ Calif Irvine, Dept Biomed Engn, Irvine, CA 92697 USA

[4] UC Irvine Med Ctr, Pumonary & Crit Care Div, Orange, CA 92868 USA

来源：

BIOMEDICAL OPTICS EXPRESS | 2011年 / 2卷 / 02期

基金：

新加坡国家研究基金会;

关键词：

NITRIC-OXIDE; BURN; BRONCHOSCOPY; INFLAMMATION; DIAGNOSIS; SHEEP;

D O I：

10.1364/BOE.2.000243

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Smoke inhalation injury is frequently accompanied by cyanide poisoning that may result in substantial morbidity and mortality, and methods are needed to quantitatively determine extent of airway injury. We utilized a 3-D endoscopic frequency-domain optical coherence tomography (FD-OCT) constructed with a swept-source laser to investigate morphological airway changes following smoke and cyanide exposure in rabbits. The thickness of the mucosal area between the epithelium and cartilage in the airway was measured and quantified. 3-D endoscopic FD-OCT was able to detect significant increases in the thickness of the tracheal walls of the rabbit beginning almost immediately after smoke inhalation injuries which were similar to those with combined smoke and cyanide poisoning. (C) 2011 Optical Society of America

引用

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页码：243 / 254

页数：12

共 33 条

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