Indium-Mediated Reformatsky Reaction of lododifluoro Ketones with Aldehydes: Preparation of α,α-Difluoro-β-hydroxyketone Derivatives in Water

被引：4

作者：

Li, Zhongyuan ^{[1
]}

Huang, Jinwen ^{[1
,2
]}

Ni, Zhuang ^{[1
]}

Sun, Ran ^{[1
]}

Nie, Hui ^{[1
]}

Tang, Hui ^{[1
]}

Song, Lixing ^{[1
]}

Wu, Fanhong ^{[1
,2
]}

机构：

[1] Shanghai Inst Technol, Sch Chem & Environm Engn, Shanghai 201418, Peoples R China

[2] Shanghai Engn Res Ctr Green Fluoropharmaceut Tech, Shanghai, Peoples R China

来源：

SYNOPEN | 2022年 / 06卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Indium; Reformatsky reaction; alpha-iodo-alpha; alpha-difluoroketone; alpha; alpha-difluoro-beta-hydroxyketone; ALKYL RADICAL-ADDITION; IODODIFLUOROMETHYL KETONES; ASYMMETRIC-SYNTHESIS; ALDOL REACTION; AQUEOUS-MEDIA; ACIDS; 2-IODO-2,2-DIFLUOROACETOPHENONES; GENERATION; ROUTE; BONDS;

D O I：

10.1055/s-0040-1719888

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Indium can efficiently mediate the Reformatsky reaction of iododifluoroacetylketones with aldehydes to afford the corresponding alpha,alpha-difluoro-beta-hydroxyketones in high yield in pure water This reaction has excellent substrate suitability and functional group selectivity and provides an efficient approach for the synthesis of bioactive molecules containing the alpha,alpha-difluoro-beta-hydroxyketone pharmacophore.

引用

页码：19 / 30

页数：12

共 45 条

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[44] Water Mediated Domino Knoevenagel-Michael-cyclocondensation Reaction of Malononitrile, Various Aldehydes and Barbituric Acid Derivatives Using Boric Acid Aqueous Solution System Compared with Nano-titania Sulfuric Acid
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