Michael reactions of titanium enolates of glycolic acid derivatives with the Weinreb and morpholine amides of acrylic acid

被引：19
|
作者：
Olivella, Anna [1 ]
Rodriguez-Escrich, Carles [1 ]
Urpi, Felix [1 ]
Vilarrasa, Jaume [1 ]
机构：
[1] Univ Barcelona, Fac Quim, Dept Quim Organ, E-08028 Barcelona, Catalonia, Spain
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2008年 / 73卷 / 04期
关键词：
D O I：
10.1021/jo702240n
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
[GRAPHICS] The conjugate additions of titanium enolates of glycolate-derived chiral oxazolidin-2-ones to various Michael acceptors have been evaluated as an entry to enantiopure 1,2,5-trioxygenated and related synthons. alpha,beta-unsaturated Weinreb and morpholine amides do react under suitable conditions and their adducts can be converted to diverse C1-C5 chiral fragments.
引用
收藏
页码：1578 / 1581
页数：4
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