Expression of adhesion molecule CD44 in metastatic brain tumors

被引：0
|
作者：
Harabin-Slowinska, M
Slowinski, J
Konecki, J
Mrowka, R
机构：
[1] Silesian Sch Med, Dept Histol & Embryol, PL-41808 Zabrze, Poland
[2] Silesian Sch Med, Dept Neurosurg & Neuro, Bytom, Poland
来源：
FOLIA NEUROPATHOLOGICA | 1998年 / 36卷 / 03期
关键词：
metastatic brain tumors; cell adhesion; CD44; glycoprotein;
D O I：
暂无
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Expression of CD44 (m.w. 80-95 kD) in 48 metastatic brain tumors was examined using monoclonal antibody on paraffin sections. The CD44 expression was found in 48% of studied tumors. The most constant expression of CD44 was observed in metastases from thyroid, skin and breast cancer. The brain metastases were characterized by quite heterogenous distribution of CD44 glycoprotein - the most pronounced expression was seen in individual neoplastic cells embedded in abundant stroma and in the vicinity of preserved neural tissue. Such a topographical distribution of CD44 supports its role in interactions of cancer cells with extracellular matrix components of the tumor stroma as well as of neural tissue.
引用
收藏
页码：179 / 184
页数：6
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