Over-expression of Flt3 induces NF-κB pathway and increases the expression of IL-6

被引：42

作者：

Takahashi, S

Harigae, H

Ishii, KK

Inomata, M

Fujiwara, T

Yokoyama, H

Ishizawa, K

Kameoka, J

Licht, JD

Sasaki, T

Kaku, M

机构：

[1] Tohoku Univ, Sch Med, Dept Clin Lab Med, Aoba Ku, Sendai, Miyagi 9808574, Japan

[2] Tohoku Univ, Sch Med, Dept Rheumatol & Hematol, Aoba Ku, Sendai, Miyagi 9808574, Japan

[3] Mt Sinai Sch Med, Dept Med, Div Hematol Oncol, New York, NY 10029 USA

来源：

LEUKEMIA RESEARCH | 2005年 / 29卷 / 08期

基金：

日本学术振兴会;

关键词：

Flt3; Nf-kappa B; IL-6; AML;

D O I：

10.1016/j.leukres.2005.01.008

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Activating mutations or over-expression of the Flt3 is prevalent in acute myeloblastic leukemia (AML), associated with activation of Ras/MAP kinase and other signaling pathways. In this study, we addressed the role of Flt3 in the activation of nuclear factor-kappa B (NF-kappa B); which is a target molecule of these kinase pathways. In BaF3 cells stably expressing 1710, a NF-kappa B-responsive reporter was upregulated and its target gene, IL-6, was increased by the involvement of Flt3-ERK/MAPK-NF-kappa B pathway. Furthermore, we found a modest positive correlation (r = 0.35, p = 0.096) between Flt3 and IL-6 mRNA expression in 24 AML specimens. These results suggest a role of Flt3 overexpression in NF-kappa B pathway. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：893 / 899

页数：7

共 50 条

[21] Cooperation of NFκB and CREB to induce synergistic IL-6 expression in astrocytes
Spooren, Anneleen
Kooijman, Ron
Lintermans, Beatrice
Van Craenenbroeck, Kathleen
Vermeulen, Linda
Haegeman, Guy
Gerlo, Sarah
CELLULAR SIGNALLING, 2010, 22 (05) : 871 - 881
[22] Expression and significance of TLR4/NF-κB/IL-6 in murine colon tissue of ulcerative colitis
Liu, Hai-Feng
Xu, Yang
Zhang, Cheng-Gang
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2013, 28 : 703 - 703
[23] Cadmium-induced IL-6 and IL-8 expression and release from astrocytes are mediated by MAPK and NF-κB
Phuagkhaopong, Suttinee
Ospondpant, Dusadee
Kasemsuk, Thitima
Sibmooh, Nathawut
Soodvilai, Sunhapas
Power, Christopher
Vivithanaporn, Pornpun
NEUROTOXICOLOGY, 2017, 60 : 82 - 91
[24] Luteolin 8-C-β-fucopyranoside downregulates IL-6 expression by inhibiting MAPKs and the NF-κB signaling pathway in human monocytic cells
Young Seoung Lee
Man Sub Kim
Dong Hun Lee
Tae Ho Kwon
Hyuk-Hwan Song
Sei-Ryang Oh
Do Young Yoon
Pharmacological Reports, 2015, 67 : 581 - 587
[25] Luteolin 8-C-β-fucopyranoside downregulates IL-6 expression by inhibiting MAPKs and the NF-κB signaling pathway in human monocytic cells
Lee, Young Seoung
Kim, Man Sub
Lee, Dong Hun
Kwon, Tae Ho
Song, Hyuk-Hwan
Oh, Sei-Ryang
Yoon, Do Young
PHARMACOLOGICAL REPORTS, 2015, 67 (03) : 581 - 587
[26] FLT3 Inhibitor Treatment Increases FLT3 Expression That Exposes FLT3-ITD+ AML Blasts to Elimination By FLT3 CAR-T Cells
Jetani, Hardikkumar
Garcia-Cadenas, Irene
Nerreter, Thomas
Goetz, Ralph
Sierra, Jorge
Bonig, Halvard
Sauer, Markus
Einsele, Hermann
Hudecek, Michael
BLOOD, 2018, 132
[27] A Novel Mutational Mechanism Drives Over-Expression of Ligand-Independent FLT3 in a Murine Model of B-Precursor ALL
Johnson, Radia
Papp, Eniko
Grandal, Ildiko
Kowalski, Paul
Wong, Peggy P. C.
Danska, Jayne S.
Guidos, Cynthia
BLOOD, 2011, 118 (21) : 293 - 293
[28] Asiaticoside Increases Caspase-9 Activity in MCF-7 Cells and Inhibits TNF-α and IL-6 Expression in Nude Mouse Xenografts via the NF-κB Pathway
Al-Saeedi, Fatma J.
MOLECULES, 2023, 28 (05):
[29] Elevated IL-6 expression in CD4 T cells via PKCθ and NF-κB induces Th2 cytokine production
Sofi, M. Hanief
Li, Wei
Kaplan, Mark H.
Chang, Cheong-Hee
MOLECULAR IMMUNOLOGY, 2009, 46 (07) : 1443 - 1450
[30] Ethanol-Induced Upregulation of IL-6 and IL-8 in Astrocytes is Mediated by the NF-κB Pathway
Gupte, R.
Shah, A.
Kumar, S.
Kumar, A.
JOURNAL OF NEUROIMMUNE PHARMACOLOGY, 2011, 6 : S31 - S32

← 1 2 3 4 5 →