Hypotonic-hyporesponsive Episodes After Diphtheria, Tetanus and Acellular Pertussis Vaccination

被引：1
|
作者：
Hansen, John [1 ]
Decker, Michael D. [2 ]
Lewis, Edwin [1 ]
Fireman, Bruce [1 ]
Pool, Vitali [2 ]
Greenberg, David P. [2 ]
Johnson, David R. [2 ]
Black, Steven [3 ]
Klein, Nicola P. [1 ]
机构：
[1] Kaiser Permanente Vaccine Study Ctr, 1 Kaiser Plaza 16B, Oakland, CA 94612 USA
[2] Sanofi Pasteur, Swillwater, PA USA
[3] Cincinnati Childrens Hosp, Cincinnati, OH USA
来源：
PEDIATRIC INFECTIOUS DISEASE JOURNAL | 2021年 / 40卷 / 12期
关键词：
hypotonic-hyporesponsive episode; diphtheria; tetanus and acellular pertussis; vaccine; adverse events following immunization; EVENT FOLLOWING IMMUNIZATION; CONTROLLED-TRIAL; DATA-COLLECTION; CASE-DEFINITION; 2-COMPONENT; GUIDELINES; HHE;
D O I：
10.1097/INF.0000000000003308
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Background: Hypotonic-hyporesponsive episode (HHE) after whole cell pertussis vaccination is a known adverse event. Less is known about the risk of HHE after administration of acellular pertussis vaccines. Methods: Using parental interviews, this study actively surveyed for HHE among infants after doses 1 and 2 of acellular pertussis vaccine. Results: We interviewed the parents of 52,531 infants. HHE was reported at a rate of 22.8 per 100,000 doses (95% CI: 11.8-39.9) of acellular pertussis vaccine, approximately 45 episodes per 100,000 children. Conclusions: These rates are lower than HHE rates reported after whole cell pertussis vaccines and within the range of HHE rates reported in other studies of acellular pertussis vaccines.
引用
收藏
页码：1122 / 1126
页数：5
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