Hypotonic-hyporesponsive Episodes After Diphtheria, Tetanus and Acellular Pertussis Vaccination

被引：1
|
作者：
Hansen, John [1 ]
Decker, Michael D. [2 ]
Lewis, Edwin [1 ]
Fireman, Bruce [1 ]
Pool, Vitali [2 ]
Greenberg, David P. [2 ]
Johnson, David R. [2 ]
Black, Steven [3 ]
Klein, Nicola P. [1 ]
机构：
[1] Kaiser Permanente Vaccine Study Ctr, 1 Kaiser Plaza 16B, Oakland, CA 94612 USA
[2] Sanofi Pasteur, Swillwater, PA USA
[3] Cincinnati Childrens Hosp, Cincinnati, OH USA
来源：
PEDIATRIC INFECTIOUS DISEASE JOURNAL | 2021年 / 40卷 / 12期
关键词：
hypotonic-hyporesponsive episode; diphtheria; tetanus and acellular pertussis; vaccine; adverse events following immunization; EVENT FOLLOWING IMMUNIZATION; CONTROLLED-TRIAL; DATA-COLLECTION; CASE-DEFINITION; 2-COMPONENT; GUIDELINES; HHE;
D O I：
10.1097/INF.0000000000003308
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Background: Hypotonic-hyporesponsive episode (HHE) after whole cell pertussis vaccination is a known adverse event. Less is known about the risk of HHE after administration of acellular pertussis vaccines. Methods: Using parental interviews, this study actively surveyed for HHE among infants after doses 1 and 2 of acellular pertussis vaccine. Results: We interviewed the parents of 52,531 infants. HHE was reported at a rate of 22.8 per 100,000 doses (95% CI: 11.8-39.9) of acellular pertussis vaccine, approximately 45 episodes per 100,000 children. Conclusions: These rates are lower than HHE rates reported after whole cell pertussis vaccines and within the range of HHE rates reported in other studies of acellular pertussis vaccines.
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页码：1122 / 1126
页数：5
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