N-Sulfonyl hydroxamate derivatives as inhibitors of class II fructose-1,6-diphosphate aldolase

被引：10

作者：

Gavalda, S ^{[1
]}

Braga, R ^{[1
]}

Dax, C ^{[1
]}

Vigroux, A ^{[1
]}

Blonski, C ^{[1
]}

机构：

[1] Univ Toulouse 3, Lab Synth & Physicochim Mol Interet Biol, Grp Chim Organ Biol, UMR 5068, F-31062 Toulouse, France

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2005年 / 15卷 / 24期

关键词：

fructose bisphosphate aldolase; N-sulfonyl hydroxamate derivatives; inhibitors; phosphonate;

D O I：

10.1016/j.bmcl.2005.09.006

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Dihydroxyacetone-phosphate and phosphonate derivatives were synthesized bearing a N-sulfonyl hydroxamate moiety. The phosphate derivatives represent competitive inhibitors for the class II-FBP aldolase catalyzed reaction, while the phosphonate isosteres are comparatively weaker inhibitors. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：5375 / 5377

页数：3

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