A generalized model of mutation-selection balance with applications to aging

被引：35

作者：

Steinsaltz, D ^{[1
]}

Evans, SN ^{[1
]}

Wachter, KW ^{[1
]}

机构：

[1] Univ Calif Berkeley, Dept Demog, Berkeley, CA 94720 USA

来源：

ADVANCES IN APPLIED MATHEMATICS | 2005年 / 35卷 / 01期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1016/j.aam.2004.09.003

中图分类号：

O29 [应用数学];

学科分类号：

070104 ;

摘要：

A probability model is presented for the dynamics of mutation-selection balance in a haploid infinite-population infinite-sites setting sufficiently general to cover mutation-driven changes in full age-specific demographic schedules. The model accommodates epistatic as well as additive selective costs. Closed form characterizations are obtained for solutions in finite time, along with proofs of convergence to stationary distributions and a proof of the uniqueness of solutions in a restricted case. Examples are given of applications to the biodemography of aging. (c) 2004 Elsevier Inc. All rights reserved.

引用

页码：16 / 33

页数：18

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