Discovering cancer biomarkers from clinical samples by protein microarrays

被引：21
|
作者：
Hu, Bin [1 ]
Niu, Xin [1 ]
Cheng, Li [2 ,3 ]
Yang, Li-Na [2 ,3 ]
Li, Qing [1 ]
Wang, Yang [1 ]
Tao, Sheng-Ce [2 ,3 ]
Zhou, Shu-Min [1 ]
机构：
[1] Shanghai Jiao Tong Univ, Shanghai Hosp 6, Inst Microsurg Limbs, Shanghai 200231, Peoples R China
[2] Shanghai Jiao Tong Univ, Shanghai Ctr Syst Biomed, Key Lab Syst Biomed, Shanghai 200231, Peoples R China
[3] State Key Lab Oncogenes & Related Genes, Shanghai, Peoples R China
来源：
PROTEOMICS CLINICAL APPLICATIONS | 2015年 / 9卷 / 1-2期
基金：
中国国家自然科学基金; 美国国家科学基金会; 国家高技术研究发展计划(863计划);
关键词：
Cancer biomarker; Cancer metastasis; Clinical samples; Protein microarray; DIFFERENTIALLY EXPRESSED PROTEINS; CELL SIGNALING ANALYSIS; BREAST-CANCER; ANTIBODY MICROARRAY; LECTIN MICROARRAY; OVARIAN-CANCER; INCREASED CIRCULATION; INTERSTITIAL FLUID; TUMOR-CELLS; IDENTIFICATION;
D O I：
10.1002/prca.201400094
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Cancer biomarkers are of potential use in early cancer diagnosis, anticancer therapy development, and monitoring the responses to treatments. Protein-based cancer biomarkers are major forms in use, as they are much easier to be monitored in body fluids or tissues. For cancer biomarker discovery, high-throughput techniques such as protein microarrays hold great promises, because they are capable of global unbiased monitoring but with a miniaturized format. In doing so, novel and cancer type specific biomarkers can be systematically discovered at an affordable cost. In this review, we give a relatively complete picture on protein microarrays applied to clinical samples for cancer biomarker discovery, and conclude this review with the future perspectives.
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页码：98 / 110
页数：13
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