Discovering cancer biomarkers from clinical samples by protein microarrays

被引：21

作者：

Hu, Bin ^{[1
]}

Niu, Xin ^{[1
]}

Cheng, Li ^{[2
,3
]}

Yang, Li-Na ^{[2
,3
]}

Li, Qing ^{[1
]}

Wang, Yang ^{[1
]}

Tao, Sheng-Ce ^{[2
,3
]}

Zhou, Shu-Min ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Shanghai Hosp 6, Inst Microsurg Limbs, Shanghai 200231, Peoples R China

[2] Shanghai Jiao Tong Univ, Shanghai Ctr Syst Biomed, Key Lab Syst Biomed, Shanghai 200231, Peoples R China

[3] State Key Lab Oncogenes & Related Genes, Shanghai, Peoples R China

来源：

PROTEOMICS CLINICAL APPLICATIONS | 2015年 / 9卷 / 1-2期

基金：

美国国家科学基金会; 国家高技术研究发展计划(863计划); 中国国家自然科学基金;

关键词：

Cancer biomarker; Cancer metastasis; Clinical samples; Protein microarray; DIFFERENTIALLY EXPRESSED PROTEINS; CELL SIGNALING ANALYSIS; BREAST-CANCER; ANTIBODY MICROARRAY; LECTIN MICROARRAY; OVARIAN-CANCER; INCREASED CIRCULATION; INTERSTITIAL FLUID; TUMOR-CELLS; IDENTIFICATION;

D O I：

10.1002/prca.201400094

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Cancer biomarkers are of potential use in early cancer diagnosis, anticancer therapy development, and monitoring the responses to treatments. Protein-based cancer biomarkers are major forms in use, as they are much easier to be monitored in body fluids or tissues. For cancer biomarker discovery, high-throughput techniques such as protein microarrays hold great promises, because they are capable of global unbiased monitoring but with a miniaturized format. In doing so, novel and cancer type specific biomarkers can be systematically discovered at an affordable cost. In this review, we give a relatively complete picture on protein microarrays applied to clinical samples for cancer biomarker discovery, and conclude this review with the future perspectives.

引用

页码：98 / 110

页数：13

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