Synthesis of 4′-Thionucleosides as Antitumor and Antiviral Agents

被引：9

作者：

Yoshimura, Yuichi ^{[1
]}

Saito, Yukako ^{[1
]}

Natori, Yoshihiro ^{[1
]}

Wakamatsu, Hideaki ^{[1
]}

机构：

[1] Tohoku Med & Pharmaceut Univ, Fac Pharmaceut Sci, Aoba Ku, 4-4-1 Komatsushima, Sendai, Miyagi 9818558, Japan

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2018年 / 66卷 / 02期

基金：

日本学术振兴会;

关键词：

nucleoside; antitumor; antiviral; 4 '-thionucleoside; antiherpes virus; Pummerer reaction; IMMUNODEFICIENCY-VIRUS TYPE-1; ANTI-HERPESVIRUS ACTIVITY; IN-VITRO; PYRIMIDINE NUCLEOSIDES; BIOLOGICAL-ACTIVITIES; GEMCITABINE; 1-(2-DEOXY-2-FLUORO-4-THIO-BETA-D-ARABINOFURANOSYL)CYTOSINE; ENANTIOMERS; DERIVATIVES; HIV;

D O I：

10.1248/cpb.c17-00636

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Many attempts have been made to synthesize structurally novel nucleoside derivatives in order to identify effective compounds for the treatment of tumors and virus-caused disease. At our laboratories, as part of our efforts to synthesize 4'-thionucleosides, we have identified and characterized biologically active nucleosides. During the course of our synthetic study, we developed the Pummerer-type thioglycosylation reaction. As a result, we synthesized a potent antineoplastic nucleoside, 1-(2-deoxy-2-fiuoro-beta-D-4-thio-arabino-furanosyl)cytosine (4'-thioFAC), and several novel 4'-thionucleosides that possess antiherpes virus activities.

引用

页码：139 / 146

页数：8

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