Radioactive Beams for Image-Guided Particle Therapy: The BARB Experiment at GSI

被引：19

作者：

Boscolo, Daria ^{[1
]}

Kostyleva, Daria ^{[1
]}

Safari, Mohammad Javad ^{[2
]}

Anagnostatou, Vasiliki ^{[2
]}

Aysto, Juha ^{[3
,4
]}

Bagchi, Soumya ^{[5
]}

Binder, Tim ^{[2
]}

Dedes, Georgios ^{[2
]}

Dendooven, Peter ^{[6
]}

Dickel, Timo ^{[1
,7
]}

Drozd, Vasyl ^{[1
,8
]}

Franczack, Bernhard ^{[1
]}

Geissel, Hans ^{[1
,7
]}

Gianoli, Chiara ^{[2
]}

Graeff, Christian ^{[1
]}

Grahn, Tuomas ^{[3
,4
]}

Greiner, Florian ^{[1
]}

Haettner, Emma ^{[1
]}

Haghani, Roghieh ^{[2
]}

Harakeh, Muhsin N. ^{[8
]}

Horst, Felix ^{[1
]}

Hornung, Christine ^{[1
,9
]}

Hucka, Jan-Paul ^{[1
,9
]}

Kalantar-Nayestanaki, Nasser ^{[8
]}

Kazantseva, Erika ^{[1
]}

Kindler, Birgit ^{[1
]}

Knoebel, Ronja ^{[1
]}

Kuzminchuk-Feuerstein, Natalia ^{[1
]}

Lommel, Bettina ^{[1
]}

Mukha, Ivan ^{[1
]}

Nociforo, Chiara ^{[1
]}

Ishikawa, Shunki ^{[10
]}

Lovatti, Giulio ^{[2
]}

Nitta, Munetaka ^{[2
]}

Ozoemelam, Ikechi ^{[11
]}

Pietri, Stephane ^{[1
]}

Plass, Wolfgang R. ^{[1
,7
]}

Prochazka, Andrej ^{[12
]}

Purushothaman, Sivaji ^{[1
]}

Reidel, Claire-Anne ^{[1
]}

Roesch, Heidi ^{[1
,9
]}

Schirru, Fabio ^{[1
]}

Schuy, Christoph ^{[1
]}

Sokol, Olga ^{[1
]}

Steinsberger, Timo ^{[1
,9
]}

Tanaka, Yoshiki K. ^{[13
]}

Tanihata, Isao ^{[14
,15
,16
]}

Thirolf, Peter ^{[2
]}

Tinganelli, Walter ^{[1
]}

Voss, Bernd ^{[1
]}

机构：

[1] GSI Helmholtzzentrum Schwerionenforsch, Darmstadt, Germany

[2] Ludwig Maximilians Univ Munchen, Munich, Germany

[3] Univ Jyvaskyla, Jyvaskyla, Finland

[4] Helsinki Inst Phys, Helsinki, Finland

[5] Indian Inst Technol, Dhanbad, Bihar, India

[6] Univ Med Ctr Groningen, Groningen, Netherlands

[7] Justus Liebig Univ Giessen, Giessen, Germany

[8] Univ Groningen, Groningen, Netherlands

[9] Tech Univ Darmstadt, Darmstadt, Germany

[10] Tohoku Univ, Sendai, Miyagi, Japan

[11] Fontys Univ Appl Sci, Eindhoven, Netherlands

[12] MedAustron, Wiener Neustadt, Austria

[13] RIKEN High Energy Nucl Phys Lab, Wako, Saitama, Japan

[14] Osaka Univ, Res Ctr Nucl Phys, Osaka, Japan

[15] Peking Univ, Beijing, Peoples R China

[16] Inst Modern Phys, Lanzhou, Peoples R China

来源：

FRONTIERS IN ONCOLOGY | 2021年 / 11卷

基金：

欧洲研究理事会;

关键词：

particle therapy; radioactive ion beams; carbon ions; oxygen ions; PET; ADENOID CYSTIC CARCINOMA; RADIATION-THERAPY; MOVING TARGETS; PROTON; RADIOTHERAPY; SYSTEM; NUCLEI; IMPLEMENTATION; SIMULATIONS; PERFORMANCE;

D O I：

10.3389/fonc.2021.737050

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Several techniques are under development for image-guidance in particle therapy. Positron (beta(+)) emission tomography (PET) is in use since many years, because accelerated ions generate positron-emitting isotopes by nuclear fragmentation in the human body. In heavy ion therapy, a major part of the PET signals is produced by beta(+)-emitters generated via projectile fragmentation. A much higher intensity for the PET signal can be obtained using beta(+)-radioactive beams directly for treatment. This idea has always been hampered by the low intensity of the secondary beams, produced by fragmentation of the primary, stable beams. With the intensity upgrade of the SIS-18 synchrotron and the isotopic separation with the fragment separator FRS in the FAIR-phase-0 in Darmstadt, it is now possible to reach radioactive ion beams with sufficient intensity to treat a tumor in small animals. This was the motivation of the BARB (Biomedical Applications of Radioactive ion Beams) experiment that is ongoing at GSI in Darmstadt. This paper will present the plans and instruments developed by the BARB collaboration for testing the use of radioactive beams in cancer therapy.

引用

页数：15

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