Hoechst 33258, a specific DNA minor groove binder

被引：0

作者：

Frau, S ^{[1
]}

Bernadou, J ^{[1
]}

Meunier, B ^{[1
]}

机构：

[1] CNRS,CHIM COORDINAT LAB,F-31077 TOULOUSE,FRANCE

来源：

BULLETIN DE LA SOCIETE CHIMIQUE DE FRANCE | 1996年 / 133卷 / 11期

关键词：

Hoechst; 33258; minor groove; DNA; recognition;

D O I：

暂无

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Following the presentation of the DNA minor groove binder Hoechst 33258, this review focuses on the recent advances in. the understanding of its mode of interaction with DNA. On the basis of a large variety of techniques, it is shown that this chromosomic dye specifically binds to designated DNA sequences with a high affinity. Syntheses of analogs and hybrid molecules designed by coupling Hoechst 33258 with chemical nucleases allow the extension of the applications of these compounds as useful tools in molecular biology and as potential pharmacenticals.

引用

页码：1053 / 1070

页数：18

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