Planar cell polarity signaling in craniofacial development

被引：19

作者：

Topczewski, Jacek ^{[1
]}

Dale, Rodney M. ^{[1
]}

Sisson, Barbara E. ^{[1
]}

机构：

[1] Northwestern Univ, Dept Pediat, Feinberg Sch Med, Childrens Mem Res Ctr, Chicago, IL 60611 USA

来源：

ORGANOGENESIS | 2011年 / 7卷 / 04期

基金：

美国国家卫生研究院;

关键词：

planar cell polarity; craniofacial development; cranial neural crest; skull formation; Wnt pathways; glypicans; HEREDITARY MULTIPLE EXOSTOSES; RECESSIVE ROBINOW-SYNDROME; RECEPTOR TYROSINE KINASE; NEURAL CREST MIGRATION; BRACHYDACTYLY TYPE-B; ENDOPLASMIC-RETICULUM; CONVERGENT EXTENSION; PALATE DEVELOPMENT; VERTEBRATE EMBRYO; SKELETAL DEFECTS;

D O I：

10.4161/org.7.4.18797

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Out of the several signaling pathways controlling craniofacial development, the role of planar cell polarity (PCP) signaling is relatively poorly understood. This pathway, originally identified as a mechanism to maintain cell polarity within the epithelial cells of the Drosophila wing, has been linked to the proper development of a wide variety of tissues in vertebrates and invertebrates. While many of the pathway members are conserved, it appears that some of the members of the pathway act in a tissue-specific manner. Here, we discuss the role of this pathway in vertebrate craniofacial development, highlighting cranial neural crest migration, skull and palate formation and the role of non-traditional modulators of PCP signaling within this developmental process.

引用

页码：255 / 259

页数：5

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