The Interrelated Transmission of HIV-1 and Cytomegalovirus During Gestation and Delivery in the Offspring of HIV-Infected Mothers

被引：3

作者：

Khamduang, Woottichai ^{[2
]}

Jourdain, Gonzague ^{[2
,3
]}

Sirirungsi, Wasna

Layangool, Prapaisri ^{[4
]}

Kanjanavanit, Suparat ^{[5
]}

Krittigamas, Pornsuda ^{[5
]}

Pagdi, Karin ^{[6
]}

Somsamai, Rosalin ^{[6
]}

Sirinontakan, Surat ^{[7
]}

Hinjiranandana, Temsiri ^{[8
]}

Ardonk, Wanna ^{[9
]}

Hongsiriwon, Suchat ^{[10
]}

Nanta, Sirisak ^{[11
]}

Borkird, Thitiporn ^{[12
]}

Lallemant, Marc ^{[2
,3
]}

McIntosh, Kenneth ^{[3
,6
]}

Ngo-Giang-Huong, Nicole ^{[1
,2
,3
]}

机构：

[1] Chiang Mai Univ, Fac Associated Med Sci, Dept Med Technol, PHPT,IRD UMI 174, Chiang Mai 50000, Thailand

[2] IRD, UMI 174, Marseilles, France

[3] Harvard Univ, Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA 02115 USA

[4] Bhumibol Adulyadej Hosp, Bangkok, Thailand

[5] Nakornping Hosp, Chiang Mai, Thailand

[6] Lamphun Prov Hosp, Lamphun, Thailand

[7] Hlth Promot Hosp Reg Ctr I, Bangkok, Thailand

[8] Somdej Pranangchao Sirikit Hosp, Chon Buri, Thailand

[9] Buddhachinaraj Hosp, Phitsanulok, Thailand

[10] Chonburi Reg Hosp, Chon Buri, Thailand

[11] Mae Sai Hosp, Mae Sai, Chiang Rai, Thailand

[12] Hat Yai Hosp, Hat Yai, Songkla, Thailand

来源：

JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES | 2011年 / 58卷 / 02期

基金：

美国国家卫生研究院;

关键词：

HUMAN-IMMUNODEFICIENCY-VIRUS; TO-CHILD TRANSMISSION; INFANTS BORN; TYPE-1; WOMEN; PROGRESSION; PREGNANCY;

D O I：

10.1097/QAI.0B013E31822D0433

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Our objective was to analyze, in formula-fed infants, correlates of HIV mother-to-child transmission, including cytomegalovirus (CMV) infection. HIV-infected infants were matched with HIV uninfected by maternal HIV RNA in a case-control design. Infant CMV infection was determined by CMV IgG at 18 months and timed by earlier CMV IgM or CMV DNA. Correlations were assessed using logistic regression. In utero HIV infection was independently associated with congenital CMV infection (P - 0.01), intrapartum HIV infection with congenital-plus-intrapartum/neonatal CMV infection (P = 0.01), and overall HIV with overall CMV infection (P = 0.001), and prematurity (P = 0.004). Congenital and acquired CMV infections are strong independent correlates of mother-to-child HIV transmission.

引用

页码：188 / 192

页数：5

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