RARE CIRCULATING TUMOR CELLS ISOLATION VIA SPIRAL-DEFORMED MICROFLUIDIC CHIP

被引：0

作者：

Gou, Yixing ^{[1
,2
]}

Ren, Dahai ^{[2
]}

You, Zheng ^{[2
]}

Sun, Changku ^{[1
]}

Wang, Peng ^{[1
]}

机构：

[1] Tianjin Univ, State Key Lab Precis Measuring Technol & Instrume, Tianjin, Peoples R China

[2] Tsinghua Univ, Dept Precis Instrument, State Key Lab Precis Measuring Technol & Instrume, Beijing, Peoples R China

来源：

2019 20TH INTERNATIONAL CONFERENCE ON SOLID-STATE SENSORS, ACTUATORS AND MICROSYSTEMS & EUROSENSORS XXXIII (TRANSDUCERS & EUROSENSORS XXXIII) | 2019年

关键词：

Circulating tumor cells isolation; inertial microfluidics; particle manipulation; lab-on-a-chip; BLOOD;

D O I：

暂无

中图分类号：

TM [电工技术]; TN [电子技术、通信技术];

学科分类号：

0808 ; 0809 ;

摘要：

This paper presents a novel spiral-deformed inertial microfluidic system to capture circulating tumor cells (CTCs) from the whole blood with high recovery rate and purity. In this chip, a 5-loop spiral channel and multiple expansion structures were designed to improve the separation performance of the spiral microfluidics based on theoretical modeling and simulations. Experiment results showed that the CTCs' recovery rate is over 90% and the purity can reach about 35%, much higher than conventional spiral microfluidics. This chip has potential to serve as a platform for cancer diagnostics analysis.

引用

页码：2286 / 2289

页数：4

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