Studying the mRNA and protein expression pattern of apoptosis and autophagy-related genes in renal cell carcinoma

被引：0
|
作者：
Yang, Wei [1 ]
Guo, Caixia [2 ]
Fan, Hui [1 ]
Liu, Feng [1 ]
Yin, Min [1 ]
机构：
[1] Jilin Univ, China Japan Union Hosp, Dept Nephrol, Changchun, Jilin, Peoples R China
[2] Jilin Univ, China Japan Union Hosp, Dept Nursing, Changchun, Jilin, Peoples R China
来源：
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE | 2017年 / 10卷 / 10期
关键词：
Autophagy; apoptosis; renal cell carcinoma; FAMILY INTERACTING MOTIF; ATG8; PROLIFERATION; MIGRATION; PATHWAYS;
D O I：
暂无
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Objective: To explore the function of autophagy and apoptosis genes (Bax, Bcl-2, Caspase-3, Caspase-8, Caspase-9, ATG2b, ATG3, ATG4a and ATG4b) in renal cell carcinoma. Methods: we analyzed the autophagy and apoptosis-related proteins expressions in human renal cell carcinomafrom the human protein atlas, applied the RT-PCR and WB to detect the mRNA and protein expressions of autophagy and apoptosis-related genes. Results: The immunohistochemistry atlas showed the autophagy and apoptosis genes all appeared an obvious change, the mRNAand protein expressions of autophagy and apoptosis genes including Bax, Caspase 3, Caspase 8, Caspase 9, ATG2b and ATG3 significantly increased, while the mRNA and protein expressions of autophagy and apoptosis genes including Bcl-2, ATG4a and ATG4b significantly decreased. Conclusion: In summary, there is significant difference in the expression of autophagy and apoptosis-related genes, indicating the participation of apoptosis and autophagy in renal cell carcinoma.
引用
收藏
页码：14593 / 14598
页数：6
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