Heterocyclic synthesis with thiophene-2-carboxamide

被引：3
|
作者：
Ahmed, Gamal A. [1 ]
机构：
[1] Zagazig Univ, Fac Sci, Dept Chem, Zagazig, Egypt
来源：
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS | 2008年 / 183卷 / 01期
关键词：
tetrahydrothienopyrimidinone; dihydrothienopyrimidine; thienopyrimidinedione; oxazinone;
D O I：
10.1080/10426500701557005
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
3-Amino-4-cyano-N-phenylaminothiophene-2-carboxamide (2) was prepared by reacting 2-(1,1-dicyanomethylene)-3-N-phenyl-1,3-thiazolidin-4-one (1) with ammonia. The carboxamide when reacted with benzaldehyde, formic acid, phenylisothiocyanate, cyclohexanone, cyclopentanone, ethylchloroformate and carbon disulfide yield. The pyrimidinone derivatives (3, 4, 5, 6, 7, 8, and 9), respectively. The biological activity of all synthesized compounds were studied as antibiotics and against Grain positive and Gram negative bacteria. The purpose of this article is synthesis of new antibiotic and antibacterial drugs.
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页码：74 / 81
页数：8
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