Cytotoxic Indole Alkaloids from Melodinus tenuicaudatus

被引：65
|
作者：
Feng, Tao [1 ,2 ]
Li, Yan [1 ]
Wang, Yuan-Yuan [1 ]
Cai, Xiang-Hai [1 ]
Liu, Ya-Ping [1 ,2 ]
Luo, Xiao-Dong [1 ]
机构：
[1] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming, Peoples R China
[2] Chinese Acad Sci, Grad Sch, Beijing, Peoples R China
来源：
JOURNAL OF NATURAL PRODUCTS | 2010年 / 73卷 / 06期
基金：
中国国家自然科学基金;
关键词：
DIMERIC ALKALOIDS; A-G; CHEMISTRY; PLANTS; HENRYI;
D O I：
10.1021/np100086x
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Four new bisindole alkaloids, melodinines H-K (1-4), a new monomer, melodinine L (5), and 11 known alkaloids were isolated from Melodinus tenuicaudatus. The structures of 1-5 were elucidated by extensive spectroscopic methods, and the known compounds were identified by comparison with data in the literature. All of the compounds were evaluated for their cytotoxicity against five human cancer cell lines, Alkaloids 3, and 4 and the known compound 11-methoxytabersonine (8) exhibited inhibitory effects, with IC50 values comparable to those of cisplatin and vinorelbine.
引用
收藏
页码：1075 / 1079
页数：5
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