The multifaceted effects of metformin on tumor microenvironment

被引:57
|
作者
Kurelac, Ivana [1 ]
Ganesh, Nikkitha Umesh [1 ]
Iorio, Maria [1 ]
Porcelli, Anna Maria [2 ,3 ]
Gasparre, Giuseppe [1 ,4 ]
机构
[1] Univ Bologna, Dipartimento Sci Med & Chirurg, Via Massarenti 9, I-40138 Bologna, Italy
[2] Univ Bologna, Dipartimento Farm & Biotecnol, Via Selmi 3, I-40126 Bologna, Italy
[3] Univ Bologna, Ctr Interdipartimentale Ric Ind Sci Vita & Tecnol, Via Tolara 41-E, I-40064 Ozzano Dell Emilia, Italy
[4] Univ Bologna, CRBA, Via Massarenti 9, I-40138 Bologna, Italy
关键词
Cancer metabolism; Metformin; Respiratory complex I; Tumor microenvironment; Angiogenesis; Cancer-associated fibroblasts; Tumor-associated macrophages; Cancer immunosuppression; BREAST-CANCER; MACROPHAGE POLARIZATION; INFLAMMATORY RESPONSE; COMPLEX I; GROWTH; INHIBITION; ANGIOGENESIS; PROGRESSION; ACTIVATION; MECHANISMS;
D O I
10.1016/j.semcdb.2019.05.010
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The efficacy of metformin in treating cancer has been extensively investigated since epidemiologic studies associated this anti-diabetic drug with a lower risk of cancer incidence. Since tumors are complex systems, in which cancer cells coexist and interact with several different types of non-malignant cells, it is not surprising that anti-cancer drugs affect not only cancer cells, but also the abundance and functions of cells of the tumor microenvironment. Recent years have seen a wide collection of reports showing how metformin, as well as other complex I inhibitors, may influence cancer progression by modulating the phenotype of non-transformed cells in a tumor. In this review, we particularly focus on the effect of metformin on angiogenesis, cancer-associated fibroblasts, tumor-associated macrophages and cancer immunosuppression.
引用
收藏
页码:90 / 97
页数:8
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