The Multifaceted Effects of Autophagy on the Tumor Microenvironment

被引:18
|
作者
Kang, Rui [1 ]
Zeh, Herbert [1 ]
Lotze, Michael [2 ]
Tang, Daolin [1 ]
机构
[1] UT Southwestern Med Ctr, Dept Surg, Dallas, TX 75390 USA
[2] Univ Pittsburgh, Dept Surg, Pittsburgh, PA USA
来源
关键词
Autophagy; Tumor microenvironment; Fibroblast; Immune cells; Cancer stem cells; Hypoxia; Inflammation; Angiogenesis; Metastasis; Metabolic reprogramming; Cell death; Cytokine; Immunosuppression; Ferroptosis; HYPOXIA-INDUCED AUTOPHAGY; CANCER STEM-CELLS; TGF-BETA; REGULATES AUTOPHAGY; TARGETING AUTOPHAGY; SELECTIVE AUTOPHAGY; ENERGY-METABOLISM; IMMUNE-RESPONSES; HMGB1; RELEASE; GROWTH;
D O I
10.1007/978-3-030-35727-6_7
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The tumor microenvironment is composed of cancer cells, noncancer cells (e.g., immune cells, stromal cells, endothelial cells, and adipocytes), and various mediators (e.g., cytokines, chemokines, growth factors, and humoral factors) that work together to support cancer growth, progression, and resistance to therapies. Autophagy is an evolutionarily conserved degradation mechanism by which various cytosolic cargos (e.g., damaged organelles, unused molecules, or invaded pathogens) are engulfed by double-membrane autophagosomes, and then delivered into the lysosome for degradation and recycling. The level of autophagy is a crucial threshold to either promote cell survival or induce cell death in response to environmental stresses. Autophagy plays a context-dependent role in tumorigenesis and anticancer therapy via shaping the inflammatory, hypoxic, immunosuppressive, and metabolic tumor microenvironment. In particular, impaired autophagy flux is associated with chronic inflammation, immunosuppression, stromal formation, cancer stemness, angiogenesis, metastasis, and metabolic reprogramming in the tumor microenvironment. Understanding the molecular machinery of autophagy and its communication with hallmarks of cancer could lead to potential new anticancer strategies or drugs.
引用
收藏
页码:95 / 110
页数:16
相关论文
共 50 条
  • [1] The multifaceted effects of metformin on tumor microenvironment
    Kurelac, Ivana
    Ganesh, Nikkitha Umesh
    Iorio, Maria
    Porcelli, Anna Maria
    Gasparre, Giuseppe
    [J]. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 2020, 98 : 90 - 97
  • [2] Tumor microenvironment is multifaceted
    Sautes-Fridman, Catherine
    Cherfils-Vicini, Julien
    Damotte, Diane
    Fisson, Sylvain
    Fridman, Wolf Herve
    Cremer, Isabelle
    Dieu-Nosjean, Marie-Caroline
    [J]. CANCER AND METASTASIS REVIEWS, 2011, 30 (01) : 13 - 25
  • [3] Tumor microenvironment is multifaceted
    Catherine Sautès-Fridman
    Julien Cherfils-Vicini
    Diane Damotte
    Sylvain Fisson
    Wolf Hervé Fridman
    Isabelle Cremer
    Marie-Caroline Dieu-Nosjean
    [J]. Cancer and Metastasis Reviews, 2011, 30 : 13 - 25
  • [4] The multifaceted role of autophagy in cancer and the microenvironment
    Folkerts, Hendrik
    Hilgendorf, Susan
    Vellenga, Edo
    Bremer, Edwin
    Wiersma, Valerie R.
    [J]. MEDICINAL RESEARCH REVIEWS, 2019, 39 (02) : 517 - 560
  • [5] Multifaceted role of redox pattern in the tumor immune microenvironment regarding autophagy and apoptosis
    Yuqing Ren
    Ruizhi Wang
    Siyuan Weng
    Hui Xu
    Yuyuan Zhang
    Shuang Chen
    Shutong Liu
    Yuhao Ba
    Zhaokai Zhou
    Peng Luo
    Quan Cheng
    Qin Dang
    Zaoqu Liu
    Xinwei Han
    [J]. Molecular Cancer, 22
  • [6] Multifaceted role of redox pattern in the tumor immune microenvironment regarding autophagy and apoptosis
    Ren, Yuqing
    Wang, Ruizhi
    Weng, Siyuan
    Xu, Hui
    Zhang, Yuyuan
    Chen, Shuang
    Liu, Shutong
    Ba, Yuhao
    Zhou, Zhaokai
    Luo, Peng
    Cheng, Quan
    Dang, Qin
    Liu, Zaoqu
    Han, Xinwei
    [J]. MOLECULAR CANCER, 2023, 22 (01)
  • [7] The role of autophagy in the tumor microenvironment
    Dower, Christopher M.
    Wang, Hong-Gang
    [J]. CANCER RESEARCH, 2016, 76
  • [8] The Multifaceted Nature of Tumor Microenvironment in Breast Carcinomas
    Annaratone, Laura
    Cascardi, Eliano
    Vissio, Elena
    Sarotto, Ivana
    Chmielik, Ewa
    Sapino, Anna
    Berrino, Enrico
    Marchio, Caterina
    [J]. PATHOBIOLOGY, 2020, 87 (02) : 125 - 142
  • [9] The Multifaceted Roles Neutrophils Play in the Tumor Microenvironment
    Sionov, Ronit Vogt
    Fridlender, Zvi G.
    Granot, Zvi
    [J]. CANCER MICROENVIRONMENT, 2015, 8 (03) : 125 - 158
  • [10] Autophagy in the crosstalk between tumor and microenvironment
    Camuzard, Olivier
    Santucci-Darmanin, Sabine
    Carle, Georges F.
    Pierrefite-Carle, Valerie
    [J]. CANCER LETTERS, 2020, 490 : 143 - 153