Synthesis of some aryl (pyrimidin-3-yl)methyl ureas, hydrazones and semicarbazones

被引：1
|
作者：
Jakubkiene, Virginija [1 ]
Zurba, Justinas [1 ]
Burbuliene, Milda M. [1 ]
机构：
[1] Vilnius State Univ, Fac Chem, Dept Organ Chem, Naugarduko 24, LT-03225 Vilnius, Lithuania
来源：
ARKIVOC | 2016年
关键词：
(Pyrimidin-3-yl)acetyl azides; aryl (pyrimidin-3-yl)ureas; hydrazones; semicarbazones; ANTIINFLAMMATORY ACTIVITY; ANTIMICROBIAL EVALUATION; SULFONAMIDE MOIETIES; DERIVATIVES; DISCOVERY; ANTIBACTERIAL; AGENTS; AZIDES; EFFICACY; THIOUREA;
D O I：
10.3998/ark.5550190.p009.620
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Two methods of synthesis of aryl (pyrimidin-3-yl)methyl ureas were investigated. One of them involved reaction sequence starting with (pyrimidin-3-yl)acetohydrazides to give the corresponding azides, which reacted with aryl amines to form aryl (pyrimidin-3-yl)methyl ureas. The second one was based on a one-pot reaction of (pyrimidin-3-yl)acetic acids with diphenyl phosphoryl azide followed by reaction with aryl amines. Also, some new aryl and (pyrimidin-3-yl)moiety bearing hydrazones and semicarbazones were synthesized.
引用
收藏
页码：374 / 386
页数：13
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