Longitudinal follow-up study of the retrobulbar and intrarenal hemodynamics in patients with T2DM

Objective: The primary aim of this study is to examine the hemodynamics of retrobulbar and intrarenal in the changes of early stage of type 2 diabetes mellitus (T2DM) patients from 2000 to 2015 and to assess incidence associated with diabetic kidney disease (DKD) and diabetic retinopathy (DR). Method: Our study contained 60 subjects newly diagnosed of T2DM were divided into 2 groups base on the mean resistive index (RI) (<= 0.7 and >0.7) of hemodynamic and to compare between-group differences of the early changes in hemodynamics of retrobulbar and intrarenal and also to conclude the incidences of diabetic kidney disease (DKD) and diabetic retinopathy (DR) subsequently with a long follow-up duration(2000-2015). First, to compare the mean RI of central retinal artery (CRA) between 2 groups. Second, to compare the mean RI of intrarenal hemodynamics in the bilateral interlobular renal arteries, renal function parameters (blood urea nitrogen (BUN), creatinine (Cr), blood glucose parameters (glycosylated hemoglobinA1c (HbA1c), fasting plasma glucose (FBG), and 2-hour postprandial blood glucose (2hPBG)), glomerular filtration rate (GFR), albumin excretion rate (AER), and urine albumin-to-creatinine ratio (UACR) between 2 groups. Results: First part of our follow-up studies was to compare hemodynamic RI index of retrobulbar in years of 2000 and 2015, both renal function and blood glucose parameters were fund significantly enhanced in subject group RIs <= 0.7. Incidence of DKD and DR was notably lower in group RIs <= 0.7 than group RIs > 0.7, difference was statistically significant (P<.05). Incidence of HbA1c <= 7% was higher in group RIs <= 0.7 than group RIs >0.7, but difference was not statistically significant (P>.05). Incidence of proliferative diabetic retinopathy (PDR) was notably lower in group RIs <= 0.7 than group RIs >0.7, but the difference was not statistically significant (P>.05). Second part of our follow-up studies was to compare hemodynamic RI index of interlobular renal in years of 2000 and 2015, both renal function and blood glucose parameters were fund significantly enhanced in subject group RIs <= 0.7. Compared data of various incidences from first part of study were coherent with second part. (Incidence of DKD and DR was notably lower in group RIs <= 0.7 than group RIs >0.7, difference was statistically significant (P<.05). Incidence of HbA1c <= 7% was higher in group RIs <= 0.7 than group RIs >0.7, but difference was not statistically significant (P>.05). Incidence of PDR was notably lower in group RIs <= 0.7 than group RIs >0.7, but the difference was not statistically significant (P>.05). Conclusions: RIs of retrobulbar and interlobular renal which would serve as a good predictors for the hemodynamics changes in retrobulbar and intrarenal would assess incidence of DKD and DR during the preclinical stage in long-term range excluding renal function and HbA1c in T2DM patients.