Highly enantioselective synthesis of 1,2-amino alcohol derivatives via proline-catalyzed Mannich reaction

被引：0
|
作者：
Pojarliev, P [1 ]
Biller, WT [1 ]
Martin, HJ [1 ]
List, B [1 ]
机构：
[1] Scripps Res Inst, Dept Mol Biol, La Jolla, CA 92037 USA
来源：
SYNLETT | 2003年 / 12期
关键词：
multicomponent reactions; organocatalysis; oxazolidinones; aminoalcohols;
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Here we report a new catalytic asymmetric synthesis of oxazolidin-2-ones 4 and Cbz-protected 1,2-amino alcohols 5. Our sequence is based on the chemistry of previously unknown 5-acyloxy-oxazolidin-2-ones, which are obtained via proline-catalyzed direct asymmetric three-component Mannich reaction and Baeyer-Villiger oxidation.
引用
收藏
页码：1903 / 1905
页数：3
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