Highly enantioselective synthesis of 1,2-amino alcohol derivatives via proline-catalyzed Mannich reaction

被引：0

作者：

Pojarliev, P ^{[1
]}

Biller, WT ^{[1
]}

Martin, HJ ^{[1
]}

List, B ^{[1
]}

机构：

[1] Scripps Res Inst, Dept Mol Biol, La Jolla, CA 92037 USA

来源：

SYNLETT | 2003年 / 12期

关键词：

multicomponent reactions; organocatalysis; oxazolidinones; aminoalcohols;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Here we report a new catalytic asymmetric synthesis of oxazolidin-2-ones 4 and Cbz-protected 1,2-amino alcohols 5. Our sequence is based on the chemistry of previously unknown 5-acyloxy-oxazolidin-2-ones, which are obtained via proline-catalyzed direct asymmetric three-component Mannich reaction and Baeyer-Villiger oxidation.

引用

页码：1903 / 1905

页数：3

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